Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"microenvironmental regulation"”.
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
<p>Cancer metastasis is the cause of about 90% of cancer patients' deaths. Despite significant improvements in the past three decades in understanding the molecular bases of oncogenic transformation of cancer cells, little is known about the molecular mechanisms underlying tumour cells' alteration …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… systems provide a means of deconstructing the microenvironmental cues which guide cell fate and function. These cues can include biochemical elements, as in ligand–receptor binding for cell–cell or cell–extracellular matrix (ECM) interactions, or responses to biophysical parameters, as in cell …
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Engineered microenvironments for studying liver progenitor differentiation
… currently undefined interactions with other microenvironmental factors, including extracellular matrix (ECM), remain barriers to complete mechanistic understanding. Utilizing a series of strategies, including co-cultures and cellular microarrays, we identified distinct contributions of …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… myeloid disorders, with a particular focus on microenvironmental regulation of myelopoiesis/megakaryopoiesis in response to neuronal inputs. During normal ageing, HSC niches decrease near bone but expand further from bone. Adrenergic signalling regulates lymphoid-myeloid balance during ageing. …
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Patterned substrates for cell culture with electrohydrodynamic jet printing
… results for a larger study to evaluate how microenvironmental stiffness and geometry influence cytoskeletal contractility and ultimately bone formation. Finally, a novel method was introduced to pattern both stiffness and chemistry at subcellular resolution. Polyacrylamide spots printed with …
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Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
Regulation of cancer cell phenotype by the tumor microenvironment has motivated further investigation into how microenvironmental factors could contribute to tumor initiation, development, and therapeutic resistance. Analyzing how the microenvironment drives tumor development and cancer cell …