Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"microenvironmental cues"”.
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… are mechanoresponsive and affected by different microenvironmental cues, including hypoxia and mechanical (un)loading. Yet, no study has focused on the role of the aforementioned factors on the adipocyte mechanical response, including actin cytoskeletal remodeling. This dissertation aims to …
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Investigating the role of geometry, mechanics, and microenvironmental cues on liver progenitor cell differentiation
Engineered systems permit investigation of the variety of signals in the microenvironment that direct cells and tissue fates. This work focuses on developing and using such systems to investigate how mechanical characteristics impact liver progenitor cell differentiation. In this dissertation, I …
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Deconstructing the influences of combinatorial microenvironmental cues on human non-parenchymal liver cells in models of liver fibrosis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
… disorders and is associated with the tendon microenvironmental changes, including disordered matrix structures, reduced stiffness and altered biochemical signalling. The effect of these microenvironmental cues on tendon cells and tendinopathy progression is poorly understood. Hypothesis: The …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
… systems allows for deconstruction of the various cues to understand the roles that they play in cell behavior and to understand how these cues can be used to modulate cell fate. Often these systems take the form of in vitro 2D monolayer cell culture, but there is a concerted effort to integrate 3D …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and differentiation are the focus of this dissertation. Cell migration occurs in several physiological and pathological …
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Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
… has motivated further investigation into how microenvironmental factors could contribute to tumor initiation, development, and therapeutic resistance. Analyzing how the microenvironment drives tumor development and cancer cell heterogeneity is particularly important in cancers such as …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
… a new chondroinductive material that can provide microenvironmental cues and signaling to promote stem cell differentiation in cartilage regeneration.
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
… found RAPTOR-dependent mTORC1 signaling couples microenvironmental cues with metabolic programs to orchestrate the reciprocal development of two fundamentally distinct T cell lineages: αβ and γδ-T cells. Loss of RAPTOR impaired αβ but promoted γδ-T cell development while disrupting metabolic …
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Influence of Peripheral Immune-Derived EphA4 on Microglial Dynamics Following Traumatic Brain Injury
… of healthy neurons. Therefore, understanding how microenvironmental cues may regulate the microglial response may aid in strategies to retool their activation state in the brain. EphA4 receptor tyrosine kinase has been identified as a potential cell-to-cell contact protein on PICs that could be …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… that while cancer cell intrinsic and tumor microenvironmental cues contribute to immune suppression, tumor extrinsic mechanisms directed by distant organs also play a critical role in determining tumor and systemic immunity. Here, we show that liver activation, specifically interleukin …
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Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
… the influence exerted on PDLIM2 by paracrine cues. Thus, PDLIM2 integrates cytoskeleton signalling with gene expression by modulating the Wnt signalling pathway and reconciling microenvironmental cues with signals in epithelial cells. Negative correlation of mRNA and protein levels in the …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
… the TIC population but the actual extracellular cues in deciphering the fate of TICs have not been explored. The basic unanswered question is the phenotypic stability of this TIC population in tissue extracellular matrix setting. This basic understanding of the TICs with its surrounding …
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ULTRA SCALABLE METHODS FOR DIFFERENTIAL TESTING OF SPATIAL-OMIC DATA
… such as gene regulation are influenced by microenvironmental cues like intercellular communication—critical for understanding development, immune responses, disease progression, and tissue regeneration. However, a key limitation of current spatial omic technologies is their resolution: most …
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BRIDGING TRANSCRIPTION AND SIGNALING TO STUDY C-MYC FUNCTION AND REGULATION IN CANCER CELLS
… role played by extracellular matrix (ECM) based microenvironmental cues in addition to the well-known growth signaling cues on MYC regulation. In summary, we identify an enhancer-specific mechanism through which MYC functions in concert with AP-1 to regulate gene expression, and demonstrate how …
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Adipose Tissue And Its Role In Modulating The Mammary Tumor Microenvironment
… In the presence of tumor-derived physicochemical cues, the host stroma fails to fulfill its primary role - the maintenance of tissue or organ homeostasis - and in fact aids in shaping a pro-tumorigenic microenvironment, ultimately promoting tumor progression. This interaction of cancer cells with …
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Tendon Regeneration: Roles of Growth Factors and Phenotypic Diversity in Tendon Stem Cells
… of the stem cells endogenous to tendon, the microenvironmental cues that induce tendon differentiation, and whether individual cells in an inflammatory milieu respond differently to these cues. To address these questions, a three-dimensional tenogenesis assay was developed as an efficient and …
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Engineering complex liver models for drug screening and infectious diseases: a biomaterials and co-culture perspective
… non-parenchymal cells (NPCs) and the proper microenvironmental cues that can play important roles in conditions such as drug-induced liver injury (DILI), which is the leading cause of the prelaunch attrition and post-market withdrawal of pharmaceuticals, or diseases such as viral hepatitis. …
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HORMONAL AND MECHANICAL CUES ON DYNAMIC CELLULAR PROCESSES IN ENDOMETRIOSIS
… investigates how hormonal and mechanical microenvironmental cues regulate dynamic cellular processes during endometriosis progression using accessible in vitro models. Our first focus is on hormonal signaling, as E2 has been widely implicated in endometriosis pathogenesis. Whether commonly …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… systems provide a means of deconstructing the microenvironmental cues which guide cell fate and function. These cues can include biochemical elements, as in ligand–receptor binding for cell–cell or cell–extracellular matrix (ECM) interactions, or responses to biophysical parameters, as in cell …
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