Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"microenvironment crosstalk"”.
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… and trigger self-propelling, aberrant signaling crosstalk with their tissue microenvironment that drives their malignant progression. Surprisingly, the non-genetic, dynamic cascade of crosstalk involves pathways often mutated in advanced metastatic SCCs with a high mutational burden. Coupling our …
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
… immunotherapy sensitivities occupy unique tumor microenvironments, a pattern that remained stable across independent tumors due to the ability of tumor clones to reprogram their surroundings. Further analysis identified a recurrent genomic alteration associated with an immunosuppressive immune …