Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1158 for “"microenvironment"”.
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
… In the brain, GSCs are supported by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high heterogeneity, vast cell-to-cell interactions, and stiff mechanical properties. To produce in vitro models …
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Cancer metastasis and elasticity of microenvironment
… mechanisms and parameters within the cellular microenvironment that initiate the onset of metastasis remain largely unknown (Chapter 1). Such a gap in the understanding and prediction of the onset of metastasis is of particular concern in colon cancer. We discovered that HCT-8 colon cancer …
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… immune responses or creating a challenging tumor microenvironment for functioning of immune cells. Modulating the tumor microenvironment with heterologous non-human proteins opens avenues for enhanced therapeutic efficacies with a minimal chance of developing resistance . In this thesis we have …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… other immunosuppressive components in the tumor microenvironment (TME) need to be targeted to elicit the full immune responses.</p> <p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic …
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… interactions (commonly referred to as the tumor microenvironment, TME), the immunology of the vitreous microenvironment and the role it plays in the sustainment of seeds in Rb disease is poorly understood. In this study, we begin investigating Rb tumor cells and how they alter the TME by …
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Exploring the tumor microenvironment of immunogenic cancers
Contains fulltext : 302594.pdf (Publisher’s version ) (Open Access)
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Modelling the neural microenvironment through biofabrication technologies
L'abstract è presente nell'allegato / the abstract is in the attachment
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Analysis of the Tumour Microenvironment in CLL
… modulated by tumour cell interactions with the microenvironment in vivo.<br/>The first part of the thesis describes in vitro assays which demonstrated that CLL cell contact with endothelial cells in a co-culture system promotes CLL cell survival. The precise mechanisms involved remain unknown, …
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… immune responses or creating a challenging tumor microenvironment for functioning of immune cells. Modulating the tumor microenvironment with heterologous non-human proteins opens avenues for enhanced therapeutic efficacies with a minimal chance of developing resistance . In this thesis we have …
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Development and Maintenance of Thymic Epithelial Microenvironment
… and selection Of T-‐cells. The thymic microenvironment, however, undergoes age related involution, Resulting in a reduction of the repertoire of T-‐cells that are produced, and a decreased Capacity to respond to new antigen. Even though significant thymic epithelial turnover occurs, it …
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CHCHD2 and the tumor microenvironment in glioblastoma
… therapies is the impact of the surrounding tumor microenvironment on intracellular signaling, which has the potential to undermine targeted treatments and advance tumor malignancy, progression, and resistance to therapy. Additionally, mitochondria, generally regarded as putative energy sensors …
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Computational profiling of the tumour immune microenvironment
… and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and widely-used approach to analyse large clinically annotated cohorts. Given …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
Intervertebral disc degeneration begins early in life, increases with age, and can ultimately result in disc failure. At the center of the disc, the nucleus pulposus (NP) resides in a hypoxic environment where degeneration is thought to begin. Initially, nucleus pulposus cells (NPCs) display …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… from these therapies; however, the tumor immune microenvironment in MSI-H EC has not yet been well described.</p> <p>In order to evaluate the immune microenvironment of MSI-H EC, multiple approaches were used, including analysis of large publically available datasets and detailed characterization …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… cells face substantial pressure within the tumor microenvironment. Physical constraints and nutrient limitations in the tumor prevent excessive cell proliferation, while other cell types such as stromal and immune cells can compete with or kill cancer cells. To overcome these restrictions, cancer …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… in adaptive immunity by providing a suitable microenvironment for developing and selecting the functional self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour …
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Graph Representation Learning to Study the Tumour Microenvironment
… cancer cells are embedded, known as the tumour microenvironment (TME). Recent technical advances allow the acquisition of highly multiplexed biomedical images (HMBI) that generate spatial tissue maps of dozens of proteins capturing the intricacies of the TME. Combining the multidimensional cell …
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A Bioinspired Approach to Engineer the Seed Microenvironment
… tardigrade and bombyx mori, we engineer the seed microenvironment to encapsulate, preserve and deliver Rhizobium tropici. Scientific discoveries in agriculture and sustainability are at the crossroads of material science, biochemistry, agriculture and biology. They underpin the innovative …
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