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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"microelectrode array"”.
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Brain microelectrode array systems
New methods for manufacturing microelectrode array assemblies, passive devices designed for intracortically recording brain activity in nonhuman primates, were developed and explored. Wire electrical discharge machining (EDM), chemical etching, micromilling, parylene deposition, and laser ablation …
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MICROELECTRODE ARRAY FOR CAPACITIVE TRANSDUCTION OF RETINAL RESPONSES
… neural activity sensing employ multi-electrode arrays (MEAs) that typically incorporate metal electrodes and measure currents via an electrochemical junction, leading to corrosion and charge transfer across the electrode-tissue interface. High-density neural interface technology will require …
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Three-Dimensional Microelectrode Array for Recording Dissociated Neuronal Cultures
… and fluidically active three-dimensional microelectrode array (3D MEA). The 3D MEA consists of a stack of individually patterned thin films that form a cell chamber conducive to maintaining and recording the electrical activity of a long-term three-dimensional network of rat cortical …
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Alternating Current Electroosmotic Micropumping Using A Square Spiral Microelectrode Array
… computer simulation model. The device SP-1 is a microelectrode array which uses the principal of AC electroosmosis (EO), ions driven along microelectrode surfaces by coulomb forces produced by tangential electric fields. These ions, when driven, induce a net fluid motion due to viscous drag …
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Surface recordings of evoked field potentials from the cerebellum with a flexmea microelectrode array
… field potentials were recorded with a FlexMEA microelectrode array from the pial surface of the paramedian lobule. The peripheral stimulation showed that the mossy and climbing fiber field potentials evoked through intramuscular stimulation were consistent with those of the literature. These …
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Microelectrode Array Modeling of Genetic Neurological Disorders in the Era of Next Generation Sequencing
… of the intact brain. CNNs plated onto multi-well microelectrode arrays (CNN-MEAs), which capture extracellular activity of electrically active cells, therefore offer a particularly appealing cellular system for the investigation of genetic variants that cause neurological disorders. </p><p>In …
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A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation
… we developed a scalable, all-organic 3D microelectrode array technology. The cheap, disposable arrays would be integrated into a fixed stimulation and imaging setup, potentially amenable to automated handling and data analysis. A combination of activity-dependent plasticity, made possible …
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Studies Toward the Development of a Microelectrode Array for Detection of Dopamine Through Redox Cycling
… electrodes. Two or more individually-addressable microelectrodes located close to each other allow redox cycling to be possible. Electrochemical behavior of a biologically important molecule, dopamine is examined under redox cycling conditions. To our knowledge, this is the first report on …
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Development of a chronically implanted microelectrode array for intraneural electrical stimulation for prosthetic sensory feedback
The functionality of prosthetic limbs is restricted by the limited availability of sensory feedback. This research aims to develop a technology to allow the presentation of sensory information directly to the sensory afferent neurons of the transected peripheral nerve in the stump of the amputee. …
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Advancing three-dimensional electrophysiology: Development and evaluation of versatile platform for tailored 3D microelectrode array fabrication
Microelectrode arrays (MEAs) are widely used tools to investigate in vitro neuronal networks and acute brain slices. Planar or 2D MEAs have been the conventional standard for decades, enabling the extracellular recording and stimulation of cultured neuronal cells and tissue slices. However, the …
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Statistical analysis of neuronal data: Development of quantitative frameworks and application to microelectrode array analysis and cell type classification
… neuronal network activity recorded on microelectrode arrays (MEAs). I perform an unbiased evaluation of the existing techniques for detecting ‘bursts’ of neuronal activity in these types of recordings, and provide recommendations for the robust analysis of bursting activity in a range …
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Towards Single-Chip Nano-Systems
… suitable for a fully integrated flexible microelectrode array has been proposed. A microelectrode array containing a single temperature sensor has been characterized and the versatility under dry/wet, and relaxed/strained conditions has been verified. On-chip instrumentation amplifier has …
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Technology development for studying information flow in biological neural networks
… Specifically, it concentrates on the penetrating microelectrode array and the micro-sized light emitting diode (µLED) coupled glass optrode array for electrophysiological recordings and optogenetic applications respectively. Since a neuron is an electrically excitable cell which is the basic …
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A system for electrical retinal stimulation for human trials
… Electrical stimulation of the retina via a microelectrode array is achieved using a battery powered stimulation system. This thesis describes the design of this system, including features that ensure the subject's safety from electrical shock. The stimulation system delivers charge balanced …
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Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays
… updated and complete procedures for use with microelectrode array (MEA) recording technology. Specific cell culture protocols, contamination prevention and control, as well common problems encountered within the cell culture facility, are discussed. This volume offers value and utility to the …
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Considerations on the use of Impedance Spectroscopy for the Detection of Virions Trapped in Quadrupolar Microelectrode Arrays
The impedance response of a quadrupolar microelectrode array was studied over a wide frequency range to determine whether particles captured at the center of the array could be detected impedimetrically. The microelectrode array (denoted as DEP chip) uses dielectrophoretic forces to concentrate …
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Electrochemical biosensor based on microfabricated electrode arrays for life sciences applications
… electrochemical sensors can be achieved by using microelectrodes and to modify the electrode surface (using chemical or biological recognition layers to improve the sensitivity and selectivity). The fabrication and characterisations of silicon-based and glass-based gold microelectrode arrays with …
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Characterisation of electrode microarrays produced photolithographically and with thiol self-assembled monolayers on gold electrodes
… qualitative advantages. The great advantage of microelectrodes over macroelectrodes is the minimisation of interference, which gives rise to much lower detection limits. Microelectrodes have much reduced ohmic drops and capacitive effects and can be used in the absence of supporting electrolyte. …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… to be combined, a transparent graphene microelectrode array (MEA) was designed, fabricated and characterised. The active electrode site was graphene since it is electrically conductive, optically transparent and biocompatible. The graphene MEA was characterised using Raman spectroscopy …
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