Global ETD Search
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Showing 1 to 2 of 2 for “"microdystrophin"”.
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Physiological adaptations in mdx mice treated with microdystrophin gene therapy and endurance exercise
… treatment currently in clinical trials is microdystrophin gene therapy, which delivers a truncated version of dystrophin to muscle via a viral vector. Preclinical studies have established efficacy of microdystrophin to improve muscle quality and function. With clinical success of this …
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The Majority of the Diaphragm Immune Transcriptome Profile Rescued in Mdx Mice by Microdystrophin Gene Therapy was maintained by Voluntary Wheel Running
… in the diaphragm of mdx mice treated with microdystrophin gene therapy with and without running wheel activity. Mdx mice are a model of Duchenne Muscular Dystrophy (DMD). Similar to DMD, mdx pathophysiology is associated with chronic inflammation due to sarcolemma fragility and cellular …