Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"microdroplets"”.
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Formation of nanoemulsions and entrapped microdroplets
Nanoeinulsions (or nano-scale emulsions) are gaining importance in diverse areas like drug delivery, development of smart food drinks, personal care, advanced material synthesis and pharmaceutics. They possess attractive properties such as high surface area, robust stability and tunable rheology. …
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Spreading behavior of molten metal microdroplets
Deposition of molten microdroplets is fundamental to many emerging droplet-based manufacturing (DBM) processes. Although the spreading behavior of ordinary liquid and molten droplets has been studied extensively for years, some basic questions remain unanswered. Specifically, the fundamental …
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Rapid detemination of antimicrobial susceptibility using gel microdroplets and flow cytometry
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1991.
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Rationalising and accelerating enzyme engineering by quantitative sequence-function profiling in microdroplets
Enzymes catalyse nearly all reactions in Nature's vast chemical repertoire with high precision and under sustainable conditions. To apply them in cost-effective and sustainable biocatalytic production processes in chemical industry, enzymes first need to be modified or "engineered" to work with …
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Concentration of Cryoprotectant in water-in-oil microdroplets for single cell vitrificaton
(cont.) Droplets with an initial concentration of IM were found to be concentrated to about 3-4M in 90s while droplets starting at 2M were concentrated to 6M in about the same time. The entire process takes place over a time scale of about one minute, fast enough to minimize exposure times but slow …
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Mammalian cell clonal growth and secretion measurements using gel microdroplets and flow cytometry
Thesis (Ph. D.)--Harvard University--Massachusetts Institute of Technology Division of Health Sciences and Technology, Program in Medical Engineering and Medical Physics, 1989.
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Preparative mass spectrometry applications in nanomaterials and organic synthesis
… focuses on the generation of charged ions from microdroplets and their use in organic synthesis and the preparation of atomically precise metal nanoclusters. First the mechanism for charging in the zero volt paper spray will be presented. This works builds a computational model based on the …
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Application of Argon Plasma Technology to Hydrophobic and Hydrophilic Microdroplet Generation in PDMS Microfluidic Devices
… create oil in water (O/W) and water in oil (W/O) microdroplets. If an argon plasma surface treatment renders the surface of PDMS hydrophilic, then O/W microdroplets can be created and integrated into a larger microdroplet emulsion device. The major aims of this project include: (1) validating …
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Dynamic Plasmonic Systems with Actuating Nanotransducers
… The dynamic behaviours of ANTs in thin-films and microdroplets are also investigated. It is observed that the thin-films undergo a reversible insulator-to-metal transition that is well captured with an effective medium model. In addition, the microdroplets are shown to mimic the optical response …
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Screening of algal cells using microdroplet technology
… tricornutum (Pt) cells were encapsulated in microdroplets and their growth was monitored over 11 days and was found to be heterogeneous. To limit cell sedimentation during encapsulation and to increase the time over which the encapsulation procedure could be run, 10% v/v OptiPrep density …
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Microfluidic Techniques for Protein Detection and Manipulation
… samples can be easily analysed. Lastly, microdroplets fabricated using two immiscible aqueous systems offer high bio-compatibility, and thus, when cross-linked with protein fibrils, would serve as optimal vehicles for drug delivery or cell encapsulation purposes.
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Simulations of interfacial dynamics of complex fluids using diffuse interface method with adaptive meshing
… in experiments, and predict self-assembly of microdroplets in nematic media.
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Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments
… to mixed to size-controlled, within water microdroplets using lightfield, darkfield, confocal, and fluorescence microscopy. We coupled this with bulk characterization techniques, in the form of spectrophotometry and light scattering, to develop a theoretical framework for understanding and …
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Enhanced phase change heat transfer through advanced fabrication techniques
… Recently, researchers have observed that when microdroplets (~10 – 100 μm) condense and coalesce on an ultra-low adhesion structured surface, the resulting excess surface energy causes the droplet to jump out of the surface against gravity. The removal of coalesced condensate droplets leads to …
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Engineering a Reverse C4 Photosynthetic Pathway in C3 species Arabidopsis thaliana
… be directly synthesised from DNA templates in microdroplets. Fluorescence corresponding to betalains was observed when part of the pathway was expressed and substrate provided. A potential future application of this system was to mimic multicellular physiological processes such as the C4 …
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Directed evolution of amino acid dehydrogenases for biocatalysis of chiral amines
… on absorbance detection. Using this new module, microdroplets could be sorted based on an absorbance readout at rates of up to 1 million droplets per hour. To demonstrate the utility of this module for protein engineering, three rounds of directed evolution were performed to improve a poorly …
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Intricate Dynamics of Droplet-Substrate Interactions Beyond Conventional Limitations
… 230 °C, fin-array-like micropillars enable water microdroplets to levitate and jump off the surface within milliseconds at just 130 °C, triggered by the inertia-controlled growth of individual vapor bubbles at the droplet base. The droplet jumping, driven by momentum interactions between the …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… of significant size shrinkage from alginate microdroplets to microspheres indicated a junction-zone mode of the cross-linking process. A particle sorting scheme combining optical detection and electric deflection was developed to deflect out capsules empty of cells and increase the yield in …
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Development of High-Performance Optofluidic Sensors on Micro/Nanostructured Surfaces
… driving a macro-size solid structure with liquid microdroplets, opening a new avenue for developing reconfigurable components such as optical switches in next-generation sensor network. Furthermore, the WGM sensing system is demonstrated to be stimulated along the meridian plane of a liquid …
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Microfluidic Approaches for Investigating Aggregated Forms of Disease-Related Proteins
… systems, as well as microfluidics to generate microdroplets that allow the direct observation of rare nucleation events leading to protein aggregation. Overall, in this work I describe the development of a novel microfluidic technique, its optimisation and application to multiple systems …
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