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Showing 1 to 15 of 15 for “"microdosimetry"”.
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Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
… at a location, and Monte Carlo simulations of microdosimetry. The second goal of this work is to implement MKM into a treatment planning system to assess the theoretical clinical impact of including variable RBE during treatment plan optimization.</p> <p>This work presents a method to calculate …
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The application of experimental microdosimetry to mixed-field neutron-gamma dosimetry
Absorbed dose distributions in lineal energy for neutrons and gamma rays were measured by using both a tissue-equivalent walled counter (TEPC) and a graphite-walled low pressure proportional counter (GPC) in the Am-Be neutron source facility at University of Ontario Institute of Technology. A …
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Design and implementation of the Hybrid Detector for Microdosimetry (HDM): Challenges in readout architecture and experimental results
… of radiation field quality through microdosimetry. Over the past 30 years, clinical results have shown that ion therapy may be a superior treatment option for several types of cancer, including recurrent cancers, compared to conventional radiation. Despite these promising results, …
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High Resolution Quantitative Auto-Radiography to determine microscopic distributions of B-10 in neutron capture therapy
… modernized, and made more user-friendly. The microdosimetry analysis software was updated to current versions of programming environments and personal computer operating systems. Verification tests were conducted to ensure the continued accuracy of the underlying algorithms. Several …
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Simulation, design and construction of a gas electron multiplier for particle tracking
… both absorbed dose and radiation quality or LET. Microdosimetry is a technique which uses a tissue equivalent gas to simulate microscopic tissue sites of the order of cellular dimensions and the principles of gas ionization devices to measure deposited energy. The Gas Electron Multiplier (GEM) has …
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Uncertainty In The Physical Basis of Estimates of Relative Biological Effectiveness In Carbon Radiotherapy
… evaluate uncertainty in current RBE models and microdosimetry techniques for estimating RBE. Most importantly, this data will be used to create a system of estimating RBE by any common model using exclusively input parameters that can be physically measured.</p> <p>This will serve as the basis …
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Quantifying Uncertainty In A Measurement-Based Assessment of Relative Biological Effectiveness In Carbon Ion Radiotherapy
… allow the assessment of RBE by RMF and LEM using microdosimetry, a method of estimating RBE from microdosimetric input values was then created with less than 5% error, on average, across all clinical energies and SOBPs.</p> <p>The impact on the RBE from eight unique random or systematic sources of …
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Personalised Risk Assessment of Low-dose Radiation Effects on Spermatogenesis
… From the point of view of radiation microdosimetry, the energy deposition of radiation from low-dose exposure (such as from environmental radiation) is localised along its track, resulting in a non-uniform distribution of exposed and unexposed cells in the irradiated tissue. To …
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Theoretical performance analysis of a novel hemispherical tissue equivalent proportional counter for neutron monitoring and dosimetry
Neutron dosimetry in reactor fields is currently conducted using thermal neutron flux monitors. It has been demonstrated that Tissue Equivalent Proportional Counters (TEPCs) have the potential to improve the accuracy of neutron dosimetry in these reactor fields, and Multi-Element Tissue Equivalent …
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Development of the Solid State Nuclear Track Detector CR-39 as a Microdosimeter for High Energy Neutron Cancer Therapy
Made available in DSpace on 2017-07-06T18:38:08Z (GMT). No. of bitstreams: 3 Durham_James_S_PhD.pdf: 309754682 bytes, checksum: 4eecbbdb6ea0eda6c19c601e5f983659 (MD5) Durham_James_S_PhD_ABS.pdf: 1292789 bytes, checksum: 5eb2a18d28c44695e61b632b8f9e8976 (MD5) license.txt: 4813 bytes, checksum: …
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Design and characterization of next-generation tissue equivalent proportional counters for use in low energy neutron fields
Tissue Equivalent Proportional Counters (TEPCs) are devices that can measure the radiation dose levels for the mixed neutron and gamma ray fields that are encountered in nuclear facilities. TEPC designs typically consist of a low density gas sensitive volume surrounded by a solid wall, each of …
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Hot particle dosimetry using a wall-less tissue equivalent proportional counter
Highly radioactive specks of irradiated nuclear fuel or activated material, colloquially known as 'hot particles', can enter the workplace or external environment from nuclear power plant operations such as refurbishment and decommissioning or from a severe nuclear accident. If deposited on the …
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A Computerized Image Analysis System for the SSNTD CR-39
Made available in DSpace on 2017-07-06T18:42:31Z (GMT). No. of bitstreams: 3 Briggs_Stephen_J_MS.pdf: 33415726 bytes, checksum: de5e59dbbe863b620fe21c74e9fd9fb8 (MD5) Briggs_Stephen_J_MS_ABS.pdf: 957747 bytes, checksum: 4750bd0e85e1075f626da29472a3bef7 (MD5) license.txt: 4813 bytes, checksum: …