Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"microdevice"”.
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A precision manipulation system for polymer microdevice production
Microfluidic science is currently going through a transition from the research laboratories to the industry as the applications and technologies increase and improve. One of the challenges of this transition is the automated production of microfluidic devices for competitive costs and production …
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Three-dimensional virus scaffolds for energy storage and microdevice applications
With constantly increasing demand for lightweight power sources, electrode architectures that eliminate the need for conductive and organic additives will increase mass specific energy and power densities. The increased demand for lightweight power is coupled with increasing device miniaturization. …
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Contactless Dielectrophoresis towards Drug Screening and Microdevice Development for Cell Sorting
Firstly, this work demonstrates that contactless dielectrophoresis (cDEP) was useful to detect a reversal in the electrical phenotype of late-stage ovarian cancer cells to a profile similar to that of slow-growing early-stage ovarian epithelial cells after treatment with a non-toxic bioactive …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… and demonstrate the use of a compartmented microdevice which allows for the isolation and study of axonal processes such as mitochondrial transport away from cell neuronal bodies. To achieve this goal, a PDMS microdevice comprised of two large chambers connected by a parallel array of …
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A nanostructured porous silicon based drug delivery device
… in this thesis. <br/><br/>The initial prototype microdevice design incorporates a porous polysilicon (PPSi) structure as a drug reservoir. Two alternative methods were investigated to fabricate the PPSi structure: i) the chemical stain etching method; ii) a reactive ion etching (RIE) method …
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Surface Functionalizations towards Nucleic Acid Purification: a nanoscale study
… mRNA under active translation. The resulting microdevice will constitute a faster, simpler and low-cost alternative to the time-consuming traditional laboratory procedures for polysome purification and mRNA extraction (sucrose gradient centrifugation and phenol/ethanol RNA extraction). …
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User Based Design of Medical Devices for Translation from Prototype to Clinical Device
… or technical skill to operate. An implantable microdevice allows for accelerated in vivo testing of anticancer agents on human derived tumors. The current method of filling the reservoirs of the microdevice with anticancer agents consists of manual stuffing of the reservoirs until the hole …
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Microblood Analyzers for the Sensitive and Portable Detection of Clinically Relevant Cardiac Markers
… order wall reaction model was used for the cFABP microdevice assay, which could predict assay behavior for a range of conditions. The pseudo-first order reaction rate was estimated at ∼1.5x10-6 m/s, and it was determined that a 40 mum wide channel operated in the desirable reaction rate …
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Microfluidic differentiation of subpopulations of cells based on their bioelectrical signature
… torques) when they are suspended in a fluid in a microdevice. A dominant force is the drag force on the particle as it flows through the fluid. External forces such as dielectrophoresis, the motion of a particle due to its polarization in the presence of a non-uniform electric field, may also be …
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High constriction ratio continuous insulator based dielectrophoretic particle sorting
… insulator based dielectrophoresis (3DiDEP) microdevice is designed to achieve continuous particle sorting based on their size and, more importantly, on their surface dielectric properties. A 3D constriction is fabricated inside Poly (methyl methacrylate) (PMMA) channels using a micromilling …
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Neuronal Polarization and Axonal mRNA Localization on Microfabricated Substrates
… second half of the dissertation utilized a PDMS microdevice to isolate purified axonal mRNA transcripts for microarray analysis. The list of axonal mRNAs generated will facilitate further studies of protein synthesis within axons, which is now a recognized process in normal axon physiology.
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Electrical and thermal transport in 2- and 3-dimensional periodic holey silicon
… design, fabricate and employ a novel integrated microdevice to measure all three thermoelectric properties of 2D holey-silicon thin films. We systematically vary doping across samples using diffusion doping over a barrier layer. While the size of the sample has minimal impact on electrical …
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Nanostructured Origami (TM) : stress-engineering of nanopatterned membranes to produce three-dimensional structures
Microdevice fabrication is done on the surface of polished flat semiconductor substrates with a series of material depositions, etches and lithography steps. These processes are inherently planar and well suited for the fabrication of billions of micrometer-thick transistors over 300 mm diameter …
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Nanoporous Gold: Mechanics of Fabrication and Actuation
… and their compatibility with the standard microdevice fabrication techniques. A galvanostatic dealloying method is introduced, and shown to be effective in fabrication of constrained, crack-free, blanket NPG films on stiff substrates. Surface stress evolution during NPG fabrication is …
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Design and operation of microchemical systems for multistep chemical syntheses
… syringe pumps push fluid through the train of microdevices. However, this pumping scheme is limited by pressure constraints at the pump drives as well as the microseparators. Therefore, there is a need to develop in-line pumps to sustain the microdevice network. Pressure-driven flow is employed …
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Micro electrochemical sensors and PCR systems: cellular and molecular tools for wine yeast analysis
… industrial communities. In the last years, many microdevices were developed for a wide range of biological applications, particularly dedicated to cellu-lar or molecular analysis. Many efforts were devoted to the realization of Cell-Based Biosensors (CBBs) to monitor the dynamic behaviour of cell …
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
… arrest, and transendothelial migration. The microdevice features self-organized human microvascular networks through which tumor cells can be perfused and tracked over time via standard confocal microscopy. In addition to improved throughput for parametric studies, robust and rapid scoring of …
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Novel molecular engineering approaches for genotyping and DNA sequencing
… throughput, miniaturization, and automation. The microdevice primarily consists of a micro-reaction chamber for single base extension and cleavage reactions with an integrated micro heater and temperature sensor for on-chip temperature control, a microchannel loaded with streptavidin magnetic …
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