Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"microbial translocation"”.
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Mononuclear phagocyte activation and its role in HIV-1 pathogenesis
… by HIV-1 and circulating LPS (marker of microbial translocation) and was associated with two clearly distinct activation profiles. At the tissue level, HIV-1 was associated with alterations in intestinal macrophage distribution, frequency and phenotype. In the colon, macrophage activation …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… PHI on inflammation, immune activation, and microbial translocation, and (ii) the effects of innovative therapeutic strategies, including dual cART regimens and long-acting injectable treatments, on immune regulation and T-cell homeostasis. The research is structured around three key …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the …
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Diagnosis, treatment and determinants of mortality in patients hospitalized with HIV-associated tuberculosis
… drug concentrations and markers of microbial translocation with 12-week mortality in hospitalized HIV-TB patients. Methods: We conducted a prospective observational cohort study and enrolled adult HIV-positive patients hospitalized with a new diagnosis of HIV-TB in Khayelitsha …
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Role of antiretroviral therapy exposure host genetics on cytomegalovirus infection status and association with gut microbiome profiles among pregnant black African women
… cells results in a leaky gut and potential gut microbial dysbiosis. In this study, we set out to determine the prevalence of CMV infection as well as factors associated with CMV reactivation in a cohort of pregnant Zimbabwean women. We also aimed to determine the role of CMV infection and CMV …
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Characterising the immunometabolic profile of HIV/TB co-infection
… changes. Loss of gut integrity and subsequent microbial translocation results in increased inflammation and immune/cytokine activation, culminating in a reduced appetite and malabsorption, which support the profile of exacerbated wasting in HIV/TB co-infected individuals. Treating HIV in the …
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Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
Chronische Immunaktivierung wird als eine wesentliche Ursachen des Fortschreitens der HIV-Infektion bis ins AIDS-Stadium angesehen. Es gibt Hinweise dafür, dass die Aktivierung von Immunzellen durch mikrobielle Translokation über die geschädigte Darmmukosabarriere verursacht wird. Um den …