Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"microbial systems"”.
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An Integrated Approach to Improving Efficiency in Photosynthetic Microbial Systems
… cyanobacteria in biotechnology. A photosynthetic microbial mat, sourced from highly productive haloalkaline soda lakes, was previously used as inoculum for enrichment of a mono-cyanobacterial microbial consortium. In this thesis, the microbial composition and function of the productive …
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Shaping Function Through Space: The Role of Spatial Organization in Microbial Communities
Spatial organization plays a critical role in microbial community function, influencing how cells exchange metabolites, coordinate behavior, and compete for resources. This thesis investigates the consequences of spatial structure in natural microbial systems and introduces a novel method to …
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Influence of enzyme location and culture rheology on glucose oxidase production and recovery by Aspergillus niger NRRL-3 and Penicillium sp. CBS120262 Madelyn Johnstone-Robertson.
… study could then be applied to other enzyme and microbial systems in which product location has been shown to be influenced by operating conditions.
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Engineering Saccharomyces ceresisiae for the Secretion of an Extracellular Lipase
<p>Developing microbial systems capable of converting low cost lipids into value added products depends on the ability to acquire substrates from the growth media. Saccharomyces cerevisiae can acquire free fatty acids from the growth media and a portion of these lipids can be converted into new …
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Metabolic engineering aimed at the production of keto acids from glycerol : an industrial by-product
… how glycerol can be used as a raw material by microbial systems to produce valuable products. The soil microbe, Pseudomonas fluorescens widely utilized in the numerous biotechnological applications due to its nutritional versatility is an obvious choice to tailor into a glycerol-transforming …
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Benthic mineralization and microscale heterogeneity
… chemical imaging to study benthic processes in systems, where the natural function of microscale heterogeneity has been ignored or improperly appreciated. The results confirm the importance of natural heterogeneity in benthic ecosystem functioning including: trace metal mobilization, microbial …
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Investigating Non-model Microorganisms for Biomanufacturing via Systems Biology and Machine Learning
… This dissertation broadly focused on improving microbial systems for industrial applications and aimed to address current limitations by 1. identifying engineered strain bottlenecks using metabolomics and 13C-isotopic tracing, 2. developing a data-driven modeling framework integrated with …
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An individual-based GPU simulation framework for collective bacterial dynamics in swarms and biofilms
… the governing forces driving the dynamics in microbial systems. Our model incorporates the biophysical processes of cell growth and division, viscous drag, bacteria self-propulsion, and mechanical cell-surface and cell-cell interactions through interaction potentials. In particular, our …
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Development of metabolic pathways for the biosynthesis of hydroxyacids and lactones
… of hydroxyacids and their lactones in multiple microbial systems. These compounds see widespread use in the production of pharmaceuticals, polymers, and fine chiral intermediates. First in this thesis, strategies and tools for metabolic pathway design are discussed. This is followed by the …
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Integrative Metagenomic Approaches to Study Antibiotic Resistance Genes and Microbial Functions in the Preterm Infant Gut Microbiome
… of antibiotic resistance genes (ARGs). As microbial colonization during this period shapes the resistome, understanding the factors driving ARG distribution and persistence are essential. This thesis investigated the distribution and genomic context of ARGs in the gut microbiome of preterm …
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Expanding the limits of Scale and sensitivity in microbial genomics
Sequencing of microbial genomes has enabled new understanding of human health and disease. Certain microbes can support human health through the microbiota, helping to train our immune system or supply essential nutrients. In other cases, microbes may be pathogenic, overwhelming the immune system …
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Geochemical changes, plant growth and ecosystem recovery in soils after high temperature remediation
… its ability to support plant growth and microbial activity. This thesis demonstrates the effects of such heating on soil properties, the impact on plant and microbial systems, and potential methods for rehabilitating soils to improve plant growth after remediation. Soils subjected to …
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Size distributions, population dynamics, and single-cell properties of marine plankton in diverse nutrient environments
… to a power law. It is hypothesized that only microbial systems with abundant nutrient inputs and, perhaps, reduced grazing pressure, have smooth spectra whose shapes conform to power laws.
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Mobile genetic elements as modulators of the human gut symbiont Bacteroides
… gene transfer (HGT) in all cellular hosts. In microbial systems, MGEs (e.g. phages, integrative and conjugative elements) are potent drivers of host evolution. Within hosts from the bacterial genus Bacteroides, one of the most common and abundant microbes in the human gut, exploration of MGE …
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Structural dynamics of community gene expression In a freshwater cyanobacterial bloom over a day-night cycle
… (structure) and activity (function) of complex microbial systems in response to dynamic environmental conditions. We have used next-generation Illumina sequencing to characterize the metatranscriptome of a tropical eutrophic drinking water reservoir dominated by the toxigenic cyanobacterium …
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Environmental Controls Over the Distribution and Function of Antarctic Soil Microbial Communities
Microbial community composition plays a vital role in soil biogeochemical cycling. Information that explains the biogeography of microorganisms is consequently necessary for predicting the timing and magnitude of important ecosystem services mediated by soil biota, such as decomposition and …
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Metabolic engineering for the production of functionalized terpenoids in heterologous hosts
… variability. As such, production in heterologous microbial systems through metabolic engineering stands as an attractive alternative to truly natural production and allows for increased control over biosynthetic pathways enabling improved yields, titer, and productivity. The anti-cancer molecule …
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APPLIED MICROBIAL ECOLOGY OF ANAEROBIC REACTOR MICROBIOMES
Open cultures of anaerobic reactor systems convert organic wastes or biomass residues into mainly short-chain carboxylates with two to five carbon atoms. The short-chain carboxylates can be converted into the highly reduced end product methane by methanogenic consortia in anaerobic digestion. …
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Exploring the factors at play to make wastewater biorefineries a reality
… of the model on different wastewater systems. The wastewater biorefinery is defined as a bioproduction system that integrates multiple unit operations to deliver compliant water as well as a bioproduct or bioproducts. It is approached through the concepts of industrial metabolism and …