Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"microbial resistance"”.
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Legacy effects of temperature alterations on microbial resistance and resilience to drying and rewetting
… arise, which have multifaceted effects on soil microbial communities. Of these, alterations to soil moisture are among the most crucial to understanding how microbial functions will change in the face of climate change. As living organisms, microbes must adapt to their environment, and their …
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Identification, isolation and bioactivity assessment of a bioactive peptide QUB-1465 from the skin secretion of Hylarana guentheri
… traditional antibiotics and solve the problem of microbial resistance as AMPs kill microorganisms through a membrane degradation mechanism, as described in the “barrel-stave-pore model”, the “toroidal-pore model” and the “carpet-like model”. In this research, a single cDNA sequence encoding a …
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Development and characterisation of photosensitiser-incorporated polymeric microparticles
… the broad-spectrum activity of photodynamic antimicrobial chemotherapy measures, and the unlikely development of microbial resistance reported, the potential for these PS- incorporated microparticles is encouraging.
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
… community and the approach toward studying anti-microbial resistance (AMR). Past studies showed that quorum sensing (QS) mutants of Pseudomonas aeruginosa, unable to produce N-acylated homoserine lactone (AHL) signals had altered biofilm structure. During mixed culture growth of P. aeruginosa …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… through exopolysaccharide (EPS) that provides microbial protection; however, the impact of EPS on detection remains uncertain. Using genome-engineered P. aeruginosa strains, we compared EPS-producers versus non-producers and a virulent E. coli pneumonia model in mice to better understand …
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A percepção dos estudantes de uma escola da rede pública na cidade de João Pessoa - PB em relação à atenção farmacêutica e o uso racional de medicamentos.
… the rational use of medication thus preventing microbial resistance, among others, and also the waste of the same population. Within these assumptions this work w as to evaluate the perceptions of high school students of a public school on the theme Pharmaceutical Care and the Rational Use of …
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Cisplatin cytotoxicity associated with tetracycline resistance determinants in Escherichia coli
… as with most antibiotics, the emergence of microbial resistance to tetracyclines has become a serious problem. Today, most genera examined have tetracycline-resistant isolates, although the percentage varies according to species and geographic location. Due to the emergence of resistance, …
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The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
Microbial resistance to antibiotics is a serious global health threat, and the discovery of new, safe and effective antibiotics is required urgently. A new class of antibiotics, namely sideophore-antibiotic conjugates, has shown promise in initial studies. Siderophores are used by bacteria for iron …
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EXTRATO E ÓLEO DE CAFÉ VERDE: FITOQUÍMICA, DESENVOLVIMENTO DE SISTEMAS NANOESTRUTURADOS E AVALIAÇÃO IN VITRO DO POTENCIAL ANTIMICROBIANO ASSOCIADO À TERAPIA FOTODINÂMICA
… acids that provide health benefits, such as antimicrobial activity, and is a natural alternative in combating antibiotic resistance, which is currently one of the main global threats to public health. In addition, antimicrobial photodynamic therapy (aPDT) has also emerged as a way to overcome …
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Assessment of antimicrobial and antiproliferative activities of a bioactive peptide from the skin secretion of white-lined leaf frog
… infections. The most effective way to prevent microbial resistance is the destruction and permeability of microbial cell membranes, because the component of microbial membrane is evolutionarily steady, so it is less likely to develop drug resistance, especially through mutations. So far, an …
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Ring distortion of the alkaloid sinomenine and novel prodrug approaches to broad-spectrum antibiotics
The continual rise of microbial resistance is a pressing concern throughout the world, resulting in several thousands of deaths each year. Most of these deaths are a result of Gram-negative infections as no new class of Gram-negative antibiotics has been introduced in several decades. The …
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Antibiotic and biocide resistance in Salmonella enterica and Escherichia coli 0157
Bacterial resistance to antibiotics and biocides is a prevalent problem, which may be exacerbated by the commonplace and often unnecessary inclusion of biocides into domestic products. Addition of antimicrobials, to domestic disinfectants has raised concern about promoting microbial resistance and …
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
… of antibiotics has caused a rise in antibiotic microbial resistance (AMR) at a time that new antibiotic discovery has slowed to a crawl. The time of picking low-hanging fruit has ended. New approaches to antibiotic discovery are sorely needed to avoid entering the “post-antibiotic era.” One …
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Structural analysis of capsular polysaccharides produced by some emerging Klebsiella pneumoniae serotypes
… (LMICs). Due to rapidly increasing anti-microbial resistance (AMR), it has been ranked among the “critical-priority 1” pathogens to human health by the World Health Organisation (WHO). K. pneumoniae produces a capsular polysaccharide (CPS or Kantigen), which constitutes an important …
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Elucidating microbial interactions, adaptations, and evolution under extreme environmental conditions in modern microbial mats from Shark Bay, Western Australia
Fossilized microbial mats dating back 2+ Ga record some of the earliest evidence of life on Earth. These ancient pustular mats preserve evidence of microbial production of extracellular polymeric substances (EPS), revealing the potential importance of EPS in the protection and preservation of these …
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Exploring the potential of UVC in treating superficial corneal infections
Microbial Keratitis (MK) is an acute, sight-threatening corneal infection. First line treatment for bacterial keratitis (BK) comprises topical antibiotics, either a dual therapy of fortified cephalosporin and aminoglycoside, or single fluoroquinolone therapy. Surveys describe increasing bacterial …
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Green supply chain management in the pharmaceutical sector: an investigation in the UK context
… and business attention due to the issue of anti-microbial resistance. Antibiotics and painkillers are continuously being deposited into the environment and are accelerating the risk of growing microbial resistance and, hence, the future of humankind is under significant threat of illness and …
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Antibiotic resistance gene abundance in feces of calves fed pirlimycin-dosed whole milk
… the incidence and proliferation of antibiotic resistance genes (ARG) in the gut and fecal microbiome. Non-saleable, antibiotic-containing milk from cows treated with antibiotics (waste milk) is commonly fed to dairy calves but the effects of ingestion of antibiotics at an early age on the gut …
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Developing a new efficient CRISPR-Cas9 base Homology Directed Repair oriented gene editing plasmid for Streptomyces
… new antibiotics at a time when rising antibiotic resistance is growing into a global health crisis. This study sought to develop a new efficient CRISPR-Cas9 gene editing plasmid that works based on the homology directed repair system in Streptomyces. The fundamental goal of the study is to …
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Structural studies of membrane-associated complexes by solid-state NMR
… Amphotericin B is a highly effective antimicrobial agent that has been used for over fifty years to treat life threatening systemic fungal infections with minimal development of microbial resistance, an increasingly critical feature with the rise of antimicrobial resistant pathogens. The …
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