Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"microbial pathogens"”.
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Polyprenyl-dependent glycan assembly pathways in microbial pathogens
Polyisoprenyl-dependent glycan assembly pathways form the basis for the biosynthesis of many complex glycoconjugates. This thesis addresses key aspects of undecaprenyl-phosphate related processes; undecaprenol is the linear polyisoprenol that is utilized by virtually all known bacterial species. In …
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Understanding the Delicate Balance between Microbial Pathogens and Insect Pests and Optimising Protection in Actinidia chinensis
Kiwifruit (Actinidia species) is a major horticultural crop. Actinidia chinensis var. chinensis ‘Hort16A’ is challenged by various biotic stressors with different lifestyles, including the hemi-biotrophic bacterial pathogen Pseudomonas syringae pv. actinidiae (psa) and the necrotrophic fungal …
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Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… are key to the survival and adaptation of microbial pathogens by enabling them to evade host immune responses and to persist in diverse environments. Pathogens respond to host immune pressures with genetic changes in surface proteins through mechanisms including point mutations, …
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Rgg2/Rgg3 Quorum Sensing in Streptococcus pyogenes and Innate Immune Cell Responses
The immune system and microbial pathogens work against each other in many ways resulting in a never-ending dance. This thesis investigates the relationship between macrophages, a type of innate immune cell, and Streptococcus pyogenes, an important human pathogen. In Chapter 2 of this thesis, it is …
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Chloroplast Biotechnology in Higher Plants: Expressing Antimicrobial Genes in the Plastid Genome
… crop species may enhance resistance to microbial pathogens and facilitate reduced pesticide load, the possibility for transmission of novel genes to wild relatives has hampered acceptance of GM crops in some markets. Chloroplast transformation presents an attractive alternative to …
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Subcellular Localization of Tobacco Salicylic Acid Binding Protein 2 in Plants.
… salicylic acid generated in plants resisting microbial infection. The precise localization of SABP2 in plants is not known. SABP2 has not been shown to have any targeting signal peptides. This study was designed to determine localization of SABP2 in tobacco plants. Biochemical and …
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Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
… lungs are especially vulnerable to infection by microbial pathogens. Pseudomonas aeruginosa is an important bacterial pathogen in chronically diseased airways, especially dominant in CF and advanced stages of COPD. Pyocyanin is a redox-active virulence factors secreted copiously in CF and COPD …
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Identification and activity assessment of a bioactive peptide QUB-2642 from the skin secretion of The American Bullfrog (Rana catesbeiana)
Global antibiotic drug resistance occurring in microbial pathogens has made antimicrobial peptides a very attractive option for new-generation antibiotics. Amongst antimicrobial peptides widespread in different classes of life, those derived from amphibians have been receiving special research …
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Smartphone-based systems for mobile infectious disease detection and epidemiology
… developing countries. The rapid detection of pathogens is vital for the control and prevention of the infectious diseases. New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications …
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Glycans in host-pathogen interactions : an integrated biochemical investigation
… makes them ideal targets for interaction with microbial pathogens. In this thesis, a framework of integrated approaches was developed to characterize the structure-function relationships of host cell surface glycans and examine their role in mediating hostpathogen interactions. The first part …
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Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages
… during and after the immune response to microbial pathogens. During the innate immune response to gram-negative bacteria, macrophages are triggered to produce numerous pro-inflammatory mediators through Toll-like receptor 4 (TLR4) binding to lipopolysaccharide (LPS). IL-10 acts on these …
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Loop mediated isothermal amplification based detection of equine respiratory pathogens using a portable, smartphone-based setup
… and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a multiplexed platform for multiplexed analysis of disease-specific DNA sequences …
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Integration of metabolic modelling with machine learning to identify mechanisms underlying antibiotic killing
Microbial pathogens are becoming a pressing global health issue due to the rapid appearance of resistant strains, accompanied by slow development of new antibiotics. In order to improve these treatments and engineer novel therapies, it is crucial that we increase our understanding of how these …
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Identification and functional analyses of a novel dermaseptin peptide from the skin secretion of the frog, Phyllomedusa duellmani
… sources of bioactive molecules acting against microbial pathogens. These bioactive components, especially the antimicrobial peptides, which possess antimicrobial and antifungal functions, have been studied in-depth. Dermaseptin peptides, derived from frogs of the Phyllomedusa genus, have been …
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Effects of Cavitation on the Removal and Inactivation of Listeria and Salmonella from the Surface of Tomatoes and Cantaloupe
… been identified as the source of bacterial pathogens that can cause human illnesses, including listeriosis and salmonellosis. Microbial pathogens may attach and form biofilms on raw fruit surfaces and can be difficult to remove. A cavitation process (formation of bubbles in water) was …
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Dissecting Transcriptional Regulation of Rpp8 in Arabidopsis thaliana
… and inducible defense responses to combat microbial pathogens. Inducible responses are mediated by R proteins, which recognize invading pathogens. R proteins must be precisely regulated to provide effective resistance, without inhibiting normal plant growth. However, little is known about R …
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IMMOBILIZATION AND CHARACTERIZATION OF FLEXIBLE DNAzyme-BASED BIOSENSORS FOR ON-THE SHELF FOOD MONITORING
… 11,600 hospitalizations and 238 deaths per year. Microbial pathogens are one of the major causes of foodborne sicknesses that can grow in food before or following packaging. Food distribution is an important part of the food processing chain, in which food supplies are at a higher risk of …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… a danger signal that warns the host of invading microbial pathogens and triggers innate immune responses including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases …
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Investigation of microbicidal activity of surface-immobilized hydrophobic polycations
… to completely kill bacterial, fungal, and viral pathogens, on-contact. Herein we describe advances with this technology on two fronts: (1) innovation of a polycationic-derivative that simplifies the labor-intensive covalent-immobilization procedure, and (2) elucidation of the current mechanistic …
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Metal sequestration of the host-defense protein human calprotectin
… are essential nutrients for all organisms. Microbial pathogens must acquire first-row transition metals such as manganese (Mn), iron (Fe), and zinc (Zn) to colonize the mammalian host and to cause disease. As part of the first line of defense against pathogenic infection, the host innate …
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