Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"microbial metabolites"”.
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Isolation, structure, synthesis, and biosynthesis of selected bioactive microbial metabolites
The biosynthetic origin of the $meta$-C$\sb7$N unit of the naphthoquinoid chromophore of the streptovaricins was shown to be 3-amino-5-hydroxybenzoic acid (AHBA) through carbon-14 and carbon-13 labeling studies. ($Carboxy$-$\sp{14}$C) AHBA was incorporated at a rate of 0.1% into streptovaricin C, …
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Investigating the Potential of Microbial Metabolites and mTOR Signaling on Chicken Necrotic Enteritis
<p>Necrotic enteritis (NE), caused by C. perfringens and coccidiosis, is responsible for substantial economic loss annually. In the first chapter, we investigated the effect of secondary bile acid on necrotic enteritis. Day-old broiler chicks were randomly assigned to 5 groups of diets supplemented …
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… were conducted. Metabolomics identified microbial-derived molecules activating iNKT cells. Mechanisms were studied using CAC murine models with or without functional iNKT cells. Increased NKT22 infiltration was observed in CAC tissues, along with enrichment of Odoribacter, a bacterium …
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Differential progression of pancreatic premalignancy in geographically distant murine transgenic cohorts uncovers key role of microbial metabolites
… dysplasia. These data suggest that this microbially dependent protective effect is specific to the cells of acinar origin. Furthermore, this independent mouse model demonstrated an increase in plasma levels of succinic acid in relation to pancreatic dysplasia, validating our …
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The effects of exercise training on the gut microbiota, microbial metabolites and microbial-host interactions in mice and humans
Embargo set by: Colleen Fallaw for item 102779 Lift date: 2019-08-10T21:27:21Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
… unabsorbed and reaches the colon where extensive microbial metabolism occurs. The objectives of these studies are to better understand the roles and activities of PCs in the lower gastrointestinal tract. First, a new high-throughput Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry …
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The role of the gut microbiota in the function and integrity of brain barriers
… between germ-free and conventional mice. Since microbial metabolites are some of the known contributing factors of the gut microbiota’s manipulation of the barriers, we next investigated the effects of physiological concentrations of short chain fatty acids (SCFAs), butyrate and propionate, with …
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Diet and exercise modulate the gut microbiome with implications for health and disease
… exercise intervention on the gut microbiota and microbial metabolites. We found that exercise training reduced insulin resistance and markers of metabolic endotoxemia, potentially due to improvements in gut barrier function. Several of these parameters correlated with baseline and …
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Investigating the potential of Sodium Butyrate to Control Salmonella Enteritidis in Poultry
… Short chain fatty acids such as butyrate are microbial metabolites known to modulate inflammatory response. In this dissertation, the effect of sodium butyrate on the colonization of SE in primary chicken enterocytes and chicken macrophages was investigated. In addition, the effect of sodium …
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Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… We subsequently identified Cholic Acid (CA), a microbial bile acid that was increased in both patients and murine models with exercise, as a likely mediator of exercise induced reduction in iCAFs. Consistent with these findings, patients that exercised more also exhibited fewer iCAFs and lower …
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EVALUATION OF YAK-KONG SOYBEAN (GLYCINE MAX) FOR ITS PHENOLICS AND METABOLITES WITH A FOCUS ON ATHEROSCLEROSIS PREVENTION
… and was evaluated its phenolics and their metabolites with a focus on prevention of CVDs. First, antioxidant activities and phenolics of YK were analyzed. In comparison to common yellow and black soybean cultivars, YK contained significantly higher concentrations of antioxidants, …
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Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
… resistance and alterations in the production of microbial metabolites. In our laboratory, we utilised the APP/PS1 transgenic mouse as a model for cerebral amyloidosis in the brain. These mice overproduce β-amyloid (Aβ), allowing the study of mechanisms of neuropathology. In this project we used …
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Gut Health Benefits of Natural and Alkali-Processed Cocoa (Theobroma cacao) with and without Inulin
… 12, and 24 hours were analyzed via HPLC-MS for microbial metabolites, applied to HT-29 colon cancer cells to assess anti-inflammatory activity, and applied to a florescence assay measuring PLA2 inhibitory activity. The alkalized cocoa powder was found to have a significantly lower concentration …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… interactions, and through production of microbial-metabolites including neurotransmitters, short chain fatty acids (SCFAs), lactate, vitamins, and S-equol. Furthermore, the gut microbiota is crucial for neurodevelopment, indicating that the gut-brain axis may be involved in pediatric …
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Rapid molecular signature analysis of pseudomonas aeruginosa by direct nanomolar detection of quorum sensing and biomarker molecules at a boron-doped diamond electrode
… simultaneous electrochemical detection of these microbial metabolites PYO, HHQ, and PQS using the BDD electrode are investigated. The detection limits obtained using the BDD electrode were 50 nM for PYO, and 250 nM for both HHQ and PQS. The direct detection of the three signaling molecules in …
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Relationships Between Hybrid Poplar Tree Extractives and Ground Water Contamination at a Phytoremediation Site
… trees were taking up PAH contaminants or their metabolites or if the rhizosphere zone created by the trees simply enhanced the ability of the site microflora to degrade the PAH. The objectives of this research were to (1) develop a suitable method for the chemical analysis of tree tissue …
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Modulation of the microbiota-gut-brain axis by fermented foods
… foods or beverages produced through controlled microbial growth, and the conversion of food components through enzymatic action. Fermented foods can serve as conduits for potentially beneficial microbes, microbial metabolites and bioactives that can serve in a functional role to confer …
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Peripheral alterations underlying the negative effects of a cafeteria diet on brain and behaviour: exercise as a mitigating strategy
… metabolic markers, inflammation, and gut-derived metabolites in males. Exercise had anxiolytic effects in males and females, induced modest improvements in spatial learning in males, and decreased spatial memory in females. Additionally, exercise mitigated a CAF diet-induced increase in …
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The impact of heptose phosphates on HIV latency and human immune responses
Use of HIV-specific antiretroviral therapeutic agents (ARTs) achieves total control of viremia and prevents progression of HIV to AIDS, but they are not a cure. Shock-and-kill therapy aims to use HIV latency reversal agents to promote clearance of HIV infected CD4 T-cells that make up the HIV …
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Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
… supernatant of the 5 strains containing secreted metabolites, given that the metabolites may induce an immunosuppressive response. The results showed significant attenuation of the inflammation of the spleen and renal lymph nodes similar to the effect of the bacteria themselves. There was also a …
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