Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"microbial infection"”.
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Impact of Temperature and Microbial Infection on the Honey Bee Hemocytes
<p>Introduction</p> <p>Honey bees (Apis mellifera) rely on hemocytes for immunity, wound healing, and hemolymph homeostasis. While 32°C reflects optimal hive conditions, suboptimal temperatures (22°C) and stressors like pathogens (Varroa destructor, bacteria) or pesticides impair hemocyte function. …
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LncRNA discovery in the Listeria monocytogenes infection model
… in host cell innate immune response against microbial infection. These discoveries and the vast numbers of uncharacterized lncRNAs identified by high-throughput nextgeneration transcriptome sequencing technologies, set a precedence for further investigation and characterization of lncRNAs in …
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Subcellular Localization of Tobacco Salicylic Acid Binding Protein 2 in Plants.
… salicylic acid generated in plants resisting microbial infection. The precise localization of SABP2 in plants is not known. SABP2 has not been shown to have any targeting signal peptides. This study was designed to determine localization of SABP2 in tobacco plants. Biochemical and …
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Investigation of differential TNFα-induced interleukin-6 gene regulation by synthesis progestins medroxyprogesterone acetate (MPA) and norethindrone acetate (NET-A) in human endocervical epithelial cells and the role of the unliganded glucocorticoid receptor
… not only serve as a physical barrier against microbial infection, but they also express a wide variety of immune mediators. The endocervical epithelial cells express a distinct profile of immune-regulators, which is higher than vaginal and ectocervical epithelial cells. Constant cytokine …
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Investigation of microbial responses to transition metal sequestration by the innate immune protein calprotectin
In response to microbial infection, the human host deploys metal-sequestering host-defense proteins to limit nutrient availability and thereby inhibit microbial growth and virulence. Calprotectin (CP) is an abundant antimicrobial protein that is released from neutrophils and epithelial cells at …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… can render host cells more susceptible to microbial infection and are also associated with a variety of human diseases ranging from cancer to neurological disorders. Moreover, viral and bacterial pathogens can exploit and modulate the host lipidation machinery to enhance infection. Robust …
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Characterized analysis of peptide QUB-1433 from the skin secretion of the dark-spotted frog (Pelophylax nigromaculatus)
… skin have been widely discovered to exhibit antimicrobial and anticancer activities. Since the antibiotic resistance has become a severe difficulty in modern therapeutic treatment, many of them have been developed into clinical application for the treatment of microbial infection and …
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The discovery of a novel bioactive peptide, QUB-2575, from the defensive skin secretion of Pelophylax kl. esculentus
… an important role in daily survival and antimicrobial peptides (AMPs) from frog skin secretions form the first line of defence against microbial infection. Due to their special antimicrobial mode of action, it is harder for bacteria to generate resistance to them. As a result, AMPs are …
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Exploring a Role for the Parkinson Disease-Linked GBA1 Gene in Host Responses to Infections
… roles for PD-linked genes in response to microbial infections in an effort to model gene-environment interactions in PD. Mutations in the GBA1 gene, encoding a protein that confers glucocerebrosidase (GCase) activity, represent the commonest risk factor for PD development. In the present …
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Infant and Childhood Infective Endocarditis in the Western Cape, South Africa: A Retrospective Review
Introduction Infective endocarditis is a microbial infection of the endothelial surface of the heart, predominantly the heart valves, that is associated with high mortality and morbidity. Few contemporary data exist regarding affected children in our context. Aims and Objectives: We aimed to …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… with crucial roles in host defense against microbial infection, autoimmune diseases and cancer. Cytosolic nucleic acids including DNA and RNA originate from pathogens or self-cells, which form major groups of PAMPs and DAMPs. A range of nucleic acid sensors have evolved to sense various …
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Regulation of Synergistic Inducible ABIN-3 Gene Expression in Response to IL-10 and LPS
… play an important role in the sensing of microbial infection and initiating innate immune responses. The activation of macrophages by pro-inflammatory stimuli, such as bacterial LPS, is mediated through changes in the expression of genes that function to promote inflammation. …
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Some Investigation into the Susceptibility and Resistance to Industrial Biocides of Fungi Important in Textile and Polyurethane Biodeterioration
… out using meadowland topsoil as a source of microbial infection. This work was extended to the colonisation of biocidally protected cellulosic substrates using the new industrial biocides, and tensile strength measurement was employed to assess the degree of biodeterioration. Some physical …
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Chemical Reporters for Bacterial Pathogenesis and Beyond
<p>Microbial infection involves complex and dynamic interplay of host defense and pathogen virulence pathways that requires new methods for mechanistic investigation. Towards this goal, I have developed chemical reporters of nucleic acid and protein synthesis and posttranslational modifications to …
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QUANTITATIVE ANALYSIS OF AGGREGATIBACTER ACTINOMYCETEMCOMITANS IN DENTAL PLAQUE SAMPLES OF MOROCCAN SCHOOL CHILDREN WITH AND WITHOUT PERIODONTITIS
Objectives: Microbial infection and the host response to the infection play a significant role in the etiology of periodontal diseases. Previous studies reported a relatively high prevalence of periodontitis among adolescents in Morocco. The importance of the composition of subgingival plaque and …
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Analysis of gene expression, regulation and function of three symbiotic ABC subfamily-B transporters in Medicago truncatula
… beneficial symbioses requires successful microbial infection. An initial exchange of signalling molecules between the host and the microbe sets off extensive transcriptional reprogramming of the host developmental programme to accommodate the incoming microbe. Microbial …
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Development of Stimulus-Responsive Ligands for the Modulation of Copper and Iron Coordination
… including iron overload, UV skin damage, and microbial infection among many other conditions. To address this concern, chelating agents that change their metal binding characteristics in response to external stimuli have been synthesized and characterized by several spectroscopic and …
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Host response of lung cells to virulent Bacillus anthracis
… of dormant spores remained viable at 24h post-infection. The “persistence” of some spores may allow them to hide long enough to avoid the first wave of the immune response and germinate later. Although the majority of MØs survived spore infection, a small percentage succumbed to infection via …
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Silver Doped Hydroxyapatite Coating on Titanium Surfaces and its Effect on Early Bone Response and Osseointegration
… due to its effect on bone response. However, microbial infection is common. One material known to have anti-microbial properties is silver (Ag). However, the effects Ag has on osteoblastic activity as well as decrease bacterial load has yet to be determined.</p> <p>In this study, the effect of …
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Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL
… in the non-specific immune system against microbial infection as they express surface receptors for the recognition of general antigenic patterns found on pathogens. In addition PMN’s also act as a mediator for the antigen-specific adaptive immunity and T-cells function. However, an …
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