Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 277 for “"microbe"”.
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Constraint-based modeling of host-microbe and microbe-microbe metabolic interactions in the human gut
… interactions but rarely in the context of host-microbe interactions. In this thesis, a framework for predicting metabolic interactions between a host and its gut symbionts was developed. As reconstructions of representative gut symbionts were lacking prior to this thesis, metabolic …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… of the microenvironment in driving the microbe-microbe and host-microbe interactions, respectively. Herein, the first part of the dissertation includes designing and engineering a synthetic E. coli killer-prey microecological system where we quantified the quorum-sensing mediated …
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Host-microbe interactions in the inflamed gut
Initiation and perpetuation of inflammatory bowel diseases (IBD) may result from an exaggerated mucosal immune response to the luminal microbiota in a susceptible host. We proposed that this may be caused either 1) by an abnormal microbial composition or 2) by weakening of the protective mucus …
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Disentangling plant-microbe interactions under environmental change
The application of nitrogen fertiliser to maintain agricultural productivity is one of the key aspects of modern farming. These activities help provide for a growing population under climate change pressures with higher intensity droughts occurring more frequently. However, such manipulations alter …
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Investigating the host-microbe dialogue in aging
… Chapter 5 built on recognising that gut microbes and the pathobiont Escherichia coli HM605 induced inflammation. This chapter also focused on the mechanisms by which Escherichia coli HM605 could influence the aging process.
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Engineering plant-microbe communication for synthetic symbioses
… in addressing this challenge. In addition, these microbes provide a promising location for genetic engineering efforts and should be viewed as an integral part of an engineerable agricultural system. This holistic view means that desired functions can be performed in the host most suitable for the …
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Deciphering the relationship among nutrition, host and microbe
… tract, there are trillions of resident microbes collectively known as the gut microbiota. These organisms have a profound impact on host physiology, particularly the immune system. Upon birth, the gut microbiota begins to take shape with input from various influences including genetics …
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Abiotic and Biotic Factors Shaping Plant-Microbe Interactions
Symbioses between plants and soil microbes can shape plant traits and performance, population dynamics, community composition, and ecosystem function. However, the context-dependency of plant-microbe interactions remains an underexplored frontier of scientific understanding. Given that the biotic …
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The Elasmobranch-Microbe Relationship: Trimethylamine n-oxide Synthesis, Urea Hydrolysis, and Microbe-Osmolyte Interactions in the Atlantic Stingray, <i>Dasyatis sabina</i>
<p>The elasmobranch osmoregulatory strategy is predicated on the accumulation of nitrogenous compounds, primarily urea and trimethylamine n¬-oxide (TMAO). Despite the abundance of these plasma osmolytes, it is notable that elasmobranchs appear to lack urease and TMA oxidase (Tmase), enzymes that …
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Background concentration of airborne microbe in new constructed building
… This study investigate the level of airborne microbe in indoor environment at three different phase of building commissioning for a new constructed building in Bandar Baru Bangi, Selangor, Malaysia. Three phases involved is after building devolves to building owner, during installation of …
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Background concentration of airborne microbe in new constructed building
… This study investigate the level of airborne microbe in indoor environment at three different phase of building commissioning for a new constructed building in Bandar Baru Bangi, Selangor, Malaysia. Three phases involved is after building devolves to building owner, during installation of …
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Sympatric Soil Microbe Interactions between Streptomyces and Fusarium Isolates
<p>Interkingdom interactions between soil bacteria and fungi may play a critical role in occurrence of disease suppressive soils, yet our understanding of these interactions remains limited. <em>Streptomyces</em> are well-known producers of antimicrobial compounds important to medicine and …
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Geographic and Host-Microbe Symbiotic Influence on Secondary Metabolism
… to the Arctic region and the importance of host-microbe interactions in natural product discovery. Bioactive metabolites have been reported from a myriad of marine and terrestrial organisms around the world including plants, insects, sponges, tunicates, bacteria, and fungi among others. Many …
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Effect of Nanoscale Surface Structures on Microbe-Surface Interactions
Bacteria in nature predominantly grow as biofilms on living and non-living surfaces. The development of biofilms on non-living surfaces is significantly affected by the surface micro/nano topography. The main goal of this dissertation is to study the interaction between microorganisms and …
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Studies of the host-microbe relationship in aquaculture-raised animals
… continue to increase. The understudied host-microbe relationship between the Eastern oyster and VP has been implicated as a path to research for potential future therapeutics. A novel culturing system for oysters was created using fermentation jars within a BSL-2 ready biosafety cabinet. …
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Mineral-Microbe Interactions Probed in Force, Energy, and Distance Nanospace
Biological force microscopy (BFM) was developed to quantitatively measure pico- to nano-Newton forces (10-9 to 10-12 N) as a function of the nanoscale distance (nanometers) between living bacteria and mineral surfaces, in aqueous solution. Native cells were linked to a force-sensing probe, which …
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The relevance of bacterial isoprenoid biosynthetic pathways for host-microbe interactions
… 4-phosphate (MEP)) for host-microbe interactions. We determined a significant reduction in microbial diversity in the murine gut microbiota (by next generation sequencing) following oral administration of a common anti-cholesterol drug Rosuvastatin (RSV) that targets mammalian …
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The impact of host-microbe interactions on murine colonic secretomotor function
… regard, I examined the impact of commensal host-microbe interactions on colonic secretomotor function in mouse. I first examined the influence of two different probiotic (microorganisms which, when given in adequate amounts, can confer health benefits upon the host) strains, Bifidobacterium …
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Interfacial and long-range electron transfer at the mineral-microbe interface
The electron transfer mechanisms of multiheme cytochromes were examined with scanning tunneling microscopy (STM). To simulate bacterial metal reduction mediated by proteins in direct contact with mineral surfaces, monolayers of purified decaheme cytochromes from the metal-reducing bacterium …
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