Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 403 for “"microRNAs"”.
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Evolutionary analysis of animal microRNAs
In recent years, microRNAs (miRNAs) have been recognised as important genetic regulators of gene expression in Animals and Plants. They can potentially target a large fraction of the cellular transcriptome, having been shown to be important for diverse biological processes such as development, cell …
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Direct Quantitative Analysis of Multiple Micrornas
MicroRNAs (miRNAs) play a significant role in gene regulation and have been shown to be deregulated in various diseases. Specific sets of deregulated miRNAs, termed miRNA fingerprints, can distinguish diseased from healthy samples. Detecting disease-specific fingerprints could be used in …
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Expression analysis of Drosophila melanogaster microRNAs
miRNAs sind endogen exprimierte winzige regulatorische RNAs mit einer Länge von 20-25 Nukleotiden. Bereits einige hundert pflanzliche und tierische miRNA Gene sind identifiziert worden. Zusammen bilden sie eine große Familie regulatorischer Moleküle, die wichtige zelluläre und …
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Targeting and function of mammalian microRNAs
In the span of a few short years, animal microRNAs have become recognized as broad regulators of gene expression, largely in part due to our improved understanding of how animal microRNAs recognize their targets. Crucial to microRNA targeting are the ~7-nt seed sites complementary to nucleotides …
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MicroRNAs in cellular transformation and tumorigenesis
MicroRNAs (miRNAs) are a novel class of small (approximately 23 nucleotides long), highly conserved, non-coding RNAs that function by broadly regulating gene expression. In animals, this regulation is achieved via interaction with target messenger RNAs (mRNAs), largely through their imperfect base …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… malignancies. A previous study identified three microRNAs that robustly suppresses breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 suppressed metastasis through inhibition of cell-autonomous metastatic phenotypes of cell migration and invasion, the role of …
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Regulation of PAX6: DNA methylation and MicroRNAs
… two mechanisms for regulation of PAX6, which are microRNAs (Study 1) and DNA methylation (Study 2 and Study 3), respectively. Study 1 examines three predicted microRNA-7 (miR-7) target sites within the 3'untranslated region (3'UTR) of the human PAX6 gene. A Luciferase reporter assay demonstrates …
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Roles of MicroRNAs in Fetal Lung Development
Lung alveolar type II cells uniquely synthesize surfactant, a developmentally-regulated lipoprotein that is essential for breathing. Expression of the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cAMP. cAMP induction of SP-A expression is …
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Functional Identification of MicroRNAs Counteracting Cellular Senescence
Cellular senescence is a process closely linked to organismal ageing, and clearance of senescent cells has been shown to revert aspects of the ageing phenotype. We sought to identify miRNAs able to counteract replicative senescence at the cellular level, and investigate their effect in vivo. A …
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Axl RTK and microRNAs in urogenital cancers
… on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a publically available cohort of …
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Stochastic modelling of gene regulation with microRNAs
The experimental and computational studies of microRNAs, a novel class of gene regulators, discovered relatively recently, is a rapidly growing field. In particular, researchers are focusing on identifying the targets of microRNAs and the roles of microRNAs in post-transcriptional gene regulation; …
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Cell Signalling and MicroRNAs: Regulation and Evolution
… of the major regulators of cell signalling are microRNAs. MicroRNAs are small non-coding sequences that regulate gene expression post-transcriptionally. As all other non-coding sequences, the significance of microRNAs has only been established recently. Today, microRNAs are known as one of the …
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The Role of MicroRNAs in Craniofacial Development
Cleft palate and orofacial clefts are common congenital anomalies whose etiology results from deficient fusion of the bilateral processes of the first pharyngeal arch and/or the frontonasal process. Craniofacial clefting can result from genetic and teratogenic disruptions affecting the growth and …
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Computational and experimental analysis of plant microRNAs
MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that mediate gene regulation in plants and animals. We demonstrated that Arabidopsis thaliana miRNAs are highly complementary (0-3 mispairs in an ungapped alignment) to more mRNAs than would be expected by chance. These mRNAs are therefore …
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Investigation of MicroRNAs in Lupus-Prone Mice
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression via inhibiting mRNA translation or degrading mRNA. Since the discovery of miRNAs, dysregulated miRNAs have been identified in human patients with various diseases. Moreover, the role of miRNAs in …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… disease with no adequate therapies. MicroRNAs (miRNAs) are dysregulated in a variety of disease states, suggesting that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA changes in ALS model SOD1G93A rodents identified …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown to provide insight into both the biology and clinical behaviour of human cancers; hence, this thesis aims to characterize both the biological function and the prognostic utility of miRNAs in NPC.First, miR-375 was …
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Regulation of Exercise-Dependent Cardiac Growth by MicroRNAs
… thesis, I present my studies on the function of microRNAs during exercise-induced cardiac remodeling. First, I show the expression of muscle-specific microRNA (miRNA), miR-499, is down-regulated by voluntary free-wheel running in hearts of mice. I hypothesized the reduction of miR-499 may be …
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Identification and Characterization of MicroRNAs Modulating Cardiac Hypertrophy
… frank dysfunction and heart failure. To identify microRNAs able to prevent cardiac hypertrophy and preserve cardiac function, we performed a high-content microscopy, high-throughput functional screening for human microRNAs able to reduce neonatal cardiomyocyte (CM) cell size using a whole-genome …
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