Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"microRNA target"”.
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Network Analysis and Comparative Phylogenomics of MicroRNAs and their Respective Messenger RNA Targets Using Twelve Drosophila species
MicroRNAs represent a special class of small (~21–25 nucleotides) non-coding RNA molecules which exert powerful post-transcriptional control over gene expression in eukaryotes. Indeed microRNAs likely represent the most abundant class of regulators in animal gene regulatory networks. This study …
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Cell Signalling and MicroRNAs: Regulation and Evolution
… of the major regulators of cell signalling are microRNAs. MicroRNAs are small non-coding sequences that regulate gene expression post-transcriptionally. As all other non-coding sequences, the significance of microRNAs has only been established recently. Today, microRNAs are known as one of the …
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Genomics and regulatory functions of microRNAs and small silencing RNAs in Arabidopsis thaliana
… of two broad classes, the ~21-nucleotide (nt) microRNAs (miRNAs) and the diverse ~22-24-nt trans-acting and heterochromatic short interfering RNAs (siRNAs). In order to more extensively characterize the small RNA landscape in plants and to identify undiscovered miRNAs and siRNAs, we performed …
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IMPLEMENTAZIONE DI DUE METODI PATHWAY TOPOLOGY-BASED PER L’ANALISI DELLA PERTURBAZIONE DI PATHWAY BIOLOGICI
… di KEGG con informazioni relative a interazioni microRNA-target e induzione dell’espressione di specifici microRNA da parte di specifici fattori della trascrizione.
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Identifying protein-coding genes and synonymous constraint elements using phylogenetic codon models
… and translation-associated regulatory motifs, microRNA target sites, RNA secondary structures, dual-coding genes, and developmental enhancers. We also develop a lineage-specific test which we use to study the evolutionary history of SCEs, and a Bayesian framework that further increases the …
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Machine Learning Approaches for Identifying microRNA Targets and Conserved Protein Complexes
… components in the cell, such as proteins, microRNAs, and genes. This dissertation focuses on two interesting problems in bioinformatics research: microRNA-target prediction and the identification of conserved protein complexes across species. We define the two problems and develop novel …
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Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat
… for the development of adult mood disorders. microRNAs (microRNAs) are small, noncoding RNAs that regulate gene expression by translational repression. microRNA altered in response to EtOH and puberty in the developing brain. The biogenesis of mature 22-24 nucleotide (nt), single-stranded …
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Verbesserung des CVB3-Maus-Myokarditismodells durch die Entwicklung pankreasattenuierter Coxsackieviren
… CVB3-Variante, welche durch die Insertion von microRNA-Zielsequenzen (microRNA-Target Sites, miRNA-TS) eine Pankreasattenuation aufweist. Die Expressionsanalyse von miRNAs im Pankreas und Herz mittels eines Affymetrix miRNA –Chip-Assays sowie quantitativer RT-PCR zeigte, dass die miRNA-375 die …
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EMISSIVE PEPTIDE NUCLEIC ACIDS (PNAS): POTENTIAL TOOLS FOR INNOVATIVE DIAGNOSTICS AND THERAPEUTICS
… of dual-action anticancer agents, in which a microRNA target will be selected for the PNA, and its antisense effect will be combined with the PDT related to the iridium complex to synergically target tumors. IV. Luminescent Pt(II) complexes as potential carriers for PNAs to bacteria Neutral …