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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 70 for “"microRNA (miRNA)"”.

  1. Effects of Mediterranean Diet and Physical AcAvity in the Improvement of Breast Cancer PaAent’s Quality of Life and microRNAs Expression: Results from the DEDiCa Study [Effetti della dieta mediterranea e dell’attività fisica sul miglioramento della qualità della vita e dell’espressione dei microRNA nelle pazienti affette da carcinoma mammario: risultati dello studio DEDiCa]

    ZANGHI', MARTAUniversità degli studi di Catania2025

    … sulla qualità della vita e sull’espressione dei microRNA (miRNA) in pazienti con carcinoma mammario. Nell’ambito del progetto clinico DEDiCa, condotto dall’Università di Catania in collaborazione con altri istituti, sono stati esaminati gli effetti di interventi dietetici e fisici sul …

    catania Repository record

  2. Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells

    Liu, Tian2011

    … a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in PIP5KIa-deficient cells than in control miRNA-expressing cells. Reintroduction of …

    ajou Repository record

  3. Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways

    Whisnant, Adam Wesley2014

    <p>The cellular microRNA (miRNA) pathway has emerged as an important regulator of host-virus interactions. While miRNAs of viral and cellular origin have been demonstrated to modulate viral gene expression and host immune responses, reports detailing these activities in the context of mammalian …

    duke Repository record

  4. Bone Characterization of Dicer Deficient Transgenic Mice Under Dmp1 Promoter

    Zainah Shaker (24399440)2026

    … and highly expressed in early-stage osteocytes. MicroRNA (miRNA) are small, single-stranded non-coding RNA molecules that function in RNA inactivation and post-transcriptional regulation of gene expression. To be fully functional, miRNAs are cleaved by the enzyme “Dicer”. This study aims to …

    uic

  5. Regulation of Exercise-Dependent Cardiac Growth by MicroRNAs

    Johnson, Brett A.2013

    … thesis, I present my studies on the function of microRNAs during exercise-induced cardiac remodeling. First, I show the expression of muscle-specific microRNA (miRNA), miR-499, is down-regulated by voluntary free-wheel running in hearts of mice. I hypothesized the reduction of miR-499 may be …

    utswmed Repository record

  6. DIAGNOSTIC APPROACH TO MYXOMATOUS MITRAL VALVE DISEASE IN CAVALIER KING CHARLES SPANIELS: IDENTIFICATION OF EARLY DIAGNOSTIC FACTORS (MORPHOMETRIC PARAMETERS AND MIRNAS EXPRESSION)

    GHILARDI, SARAUniversità degli Studi di Milano2025

    … morphometric parameters with circulating microRNA (miRNA) expression. To accomplish this, three complementary studies were conducted, combining molecular, echocardiographic, and morphometric approaches to enhance the understanding of disease onset and progression. The first study was a …

    milano Repository record

  7. CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS

    Gillespie, AriaTemple University. Libraries2024

    … and examine expression of potential circGrin2b microRNA (miRNA)-sponge targets. We validated circGrin2b interactions with miR-26b-3p and miR-100-3p utilizing a luciferase binding assay. Sponging of these 2 miRNA targets can have extensive impact of translation of miRNA-repressed genes, as both …

    temple Repository record

  8. Impacts of microRNAs on Skeletal Muscle Protein Synthesis and Mitochondrial Quality

    Lee, David2017

    <p>microRNA (miRNA) post-transcriptional modification is becoming a well-established mechanism for controlling mRNA translation. microRNAs -1, -133, and -206 are under the control of skeletal muscle promoters and affect muscle plasticity and metabolic health. A detailed review on the generation and …

    arkansas Repository record

  9. Regulation of Skeletal Muscle Innervation and ALS Pathogenesis by MicroRNA 206

    Williams, Andrew H.2011

    … thesis, I present my studies on the function of microRNAs in neuromuscular synapse regeneration and neurodegenerative disease. First, I show that the expression of a muscle-specific microRNA (miRNA), miR-206, is dramatically upregulated following surgical denervation of skeletal muscle and in a …

    utswmed Repository record

  10. Exploring the global gene expression programs and regulation in the response of quiescent human fibroblasts to distinct proliferative stimuli

    Gu, JianThe University of Texas at Austin2005

    … which was not observed in the Myc data. MicroRNA (miRNA) expression profiling indicated that let7 and other miRNAs with similar expression profiles may be involved in regulating the transcriptional program in response to proliferative signals. Our results indicate that conservation of …

    texas Repository record

  11. Inhibition of the autophagy pathway modulates osteosarcoma chemoresistance

    Pereira, J.Middlesex University2023

    … autophagic clearance of p62. Autophagy-related microRNA (miRNA) expression was found to be decreased in chemotherapy-treated HOS-143B cells. To investigate the role of the key autophagy gene ATG7, CRISPR/Cas9 technology was employed to disrupt ATG7 (ATG7-/-), resulting in the inhibition of …

    middlesex

  12. A cause for consilience: Utilizing multiple genomic data types to resolve problematic nodes within Arthropoda and Ecdysozoa

    Campbell, Lahcen I.National University of Ireland Maynooth2012

    … data sets was investigated. EST and rRNA and microRNA (miRNA) data were sampled across all major ecdysozoan phyla. In particular, a major contribution of this thesis is the first time sequencing of miRNAs for all the panarthropod phyla. MicroRNAs are genome regulatory elements that recently …

    maynooth Repository record

  13. MicroRNA expression and function in neonatal hypoxic ischaemic encephalopathy

    Looney, Ann-MarieUniversity College Cork2016

    … biomarker of HIE severity must be identified. MicroRNA (miRNA) are a class of small non-coding RNA molecules which have potential as biomarkers of disease state and potential therapeutic targets. These tiny molecules can modulate gene expression by inhibiting translation of messenger RNA (mRNA) …

    cork Repository record

  14. Mammalian gene regulation through the 3' UTR

    Nielsen, Cydney BrookeMassachusetts Institute of Technology2008

    … the message. We explored two classes of motifs, microRNA (miRNA) complementary sites and cleavage and polyadenylation (poly(A)) signals, and provide evidence that specific sequence contextual features are important for their recognition. MiRNAs are 22 nt, non-coding RNAs that function as …

    mit Repository record

  15. Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer

    Björner, SofiePathology (Malmö)2013

    … We have also observed that the expression of the microRNA (miRNA) miR-92a could provide independent prognostic information in breast cancer patients, and loss of miR-92a was associated with more severe breast cancer traits. The earliest histologically identifiable breast lesion with an increased …

    lund Repository record

  16. The Role of MicroRNAs in Craniofacial Development

    Miller, Joseph M.Creighton University2010

    … arch have been studied; however, the role of microRNA (miRNA) in mammalian palatal development has not been elucidated. miRNA are a class of short 19-21 nt noncoding RNA whose function is in the repression and attenuation of translation of their target mRNA. The function of specific miRNA is …

    creighton Repository record

  17. Prostate Cancer and the Search for Novel Biomarkers

    Haj-Ahmad, Taha AlexanderBrock University2013

    … genome (DNA); (2) the transcriptome (mRNA and miRNA); and (3) the proteome. Toward this end, urine samples were collected from ten healthy individuals, eight men with PCa and twelve men with enlarged, non-cancerous prostates or with Benign Prostatic Hyperplasia (BPH). Urine samples were also …

    brock Repository record

  18. Robustness and tunability in biological networks/ by Shankar Mukherji.

    Mukherji, Shankar, 1982-Massachusetts Institute of Technology2010

    … we turn our attention to gene regulation by microRNA (miRNA). MiRNAs are short regulatory RNA molecules that repress gene expression in a sequence-dependent manner. By observing the strength of miRNA-mediated repression in individual cells, we show that the strength of repression depends …

    mit Repository record

  19. Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2

    Jeyapalan, Zina2012

    … plays a significant role in the regulation of microRNA (miRNA) functions. The 3’UTR is hypothesized to function in the feed-back regulation of miRNA functions, since it can bind and inactivate multiple miRNAs. In this study, the effects of the exogenous over-expression of two 3’UTRs, CD44 and …

    toronto-retro Repository record

  20. Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by altering the expression of key angiogenic genes

    Ahmed, SuhailUniversity of Wolverhampton2023

    … by excessive or insufficient angiogenesis. MicroRNA (miRNA) are small non-coding RNA molecules, which inhibit gene expression by inducing mRNA degradation or suppressing protein translation. Emerging evidence highlights a novel role for miRNAs as regulators of angiogenesis. In endothelial …

    wlv Repository record

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