Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"microPET imaging"”.
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Characterizing the modulation of mGluR5 in a 6-OHDA-induced rat model of Parkinson's disease
MicroPET imaging studies were conducted to investigate the role of metabotropic glutamate subtype-5 receptors (mGluR5) in Parkinson's disease (PD). Four analogical PET ligands were used to characterize modulation of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral …
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Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non-Invasive Mechanical Loading
… a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… in vivo, are limited4. Therefore, functional imaging techniques, such as positron emission tomography (PET), may be useful for understanding the complex role of the endocannabinoid system in animals and humans. Our major focus was to prepare novel fluorinated analogs of tetrahydrocannabinol …
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… class of radiopharmaceuticals for diagnostic imaging and cancer therapy. Following radionuclide labeling, the specific receptor-binding properties of the ligand can be exploited to guide the radioactivity to tissues expressing a particular receptor. This dissertation reports on the development …