Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"micro-RNA"”.
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… function role of Farnesoid X receptor (FXR) and microRNA-34 (miR-34a), as key transcriptional and post-transcriptional regulators respectively, in maintaining metabolic hemostasis and energy balance. Nuclear receptors (NRs) are lipophilic ligand-dependent transcriptional factors that regulate the …
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A Platform for Fast Detection of Let-7 Micro RNA Using Polyaniline Fluorescence and Image Analysis Techniques
… is robust and is capable of detecting specific RNAs in extracts from animals. This sensor system improves on previously reported strategies by transducing highly specific probe dissociation events through intrinsic properties of a conducting polymer without the need for additional labels. The …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… activation and increased secretion of platelet micro-particles that induce angiogenesis. This study determined the role of platelet micro-particles derived microRNA in the regulation of angiogenesis and migration, with a focus on the regulation of thrombospondin-1 release by platelet …
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
… may allow to improve TGCTs management. 371a-p microRNA showed the ability to identify vital cancer in GCTs and its performance in term of sensitivity and specificity exceed the available markers. We tested its diagnostic accuracy in small testicular masses and in low volume retroperitoneal …
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Effetto dell’esposizione cronica volontaria di eroina e WIN55,212-2 sull’espressione di micro RNA nelle aree cerebrali coinvolte nella dipendenza da sostanze d’abuso
Micro RNAs (miRNA) are 21-25 nucleotide endogenous non coding RNAs that regulate gene expression at the post-transcriptional level through binding to a target complementary mRNA. Targeted mRNAs are translationally inhibited or subjected to degradation by miRNAs, depending on the complementarity in …
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Regulation of estrogen receptor-alpha mediated gene expression and endocrine resistance through estrogen receptor-alpha phosphorylation and micro-RNA in breast cancer
… breast cancer. We also studied the regulation of microRNAs (miRNAs) by estradiol and growth factors through ER and extracellular signal-regulated kinase 2 (ERK2) in order to understand their physiological impact on breast cancer. We identified nine miRNA- encoding genes harboring overlapping ER …
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
… bronchiole density (MTBD), and expression of mRNA and micro-RNA was determined. Results: Fifteen CDH, 15 CDH+TO, 6 sham CDH, and 15 controls were included in the study. LBWR was low in CDH while CDH+TO was similar to controls. MTBD was higher in CDH fetuses and restored to control levels in …
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Biomarcadores sanguíneos predictivos de respuesta al tratamiento anti-VEGF en degeneración macular asociada a la edad
… compuesto por 4 ácidos ribonucleicos (RNA) y 1 micro RNA (miRNA) aislado de PBMCs fue capaz de predecir la respuesta a ranibizumab con alta precisión (área bajo la curva de la característica operativa del receptor = 0,968) antes del tratamiento. De acuerdo con los resultados, se …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… DNA, circulating tumour DNA, cell-free messenger RNA, and bloodborne tumour related proteins as disease biomarkers in patients with glioma and metastatic melanoma. The in vivo research work employed an animal model to study micro RNA mediated epigenetic regulatory mechanisms implicated in …
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Antioxidant pathways and human leukaemia chemotherapeutic sensitivity
… in response to both cytotoxic agents. Upon micro RNA (miRNA) silencing of HO-1 expression, both ara-C and DNR stimulated greater apoptotic responses in these silenced AML cells. A concurrent induction in reactive oxygen species (ROS) generation was observed. Studies with ara-C-resistant AML …
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Nutritional Strategies to Improve Pig Growth and Performance
… satellite cell function which may be mediated by micro-RNA. Differentiation promoting miR-206 and correspondingly the fusion rate was highest in adequate calcium phosphate diets. Excess protein diets enhanced body and muscle growth, while deficient protein was detrimental to growth. Dietary …
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Mammaprint nella scelta terapeutica del carcinoma della mammella
… gli altri, dati relativi all espressione dell mRNA, informazioni sulla metilazione del DNA e sulle mutazioni puntiformi del DNA. Inoltre si è proceduto al sequenziamento del micro RNA e del completo esone e ed alla misurazione dell espressione di alcune proteine. I carcinomi mammari possono …
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Physiological and Molecular Consequences of Large Y Chromosome Long Arm Deletions in Mice
… between these populations were analysed by microarray and RNA sequencing analysis of total and micro RNA. This work yielded a collection of coding and non-coding transcripts which show distinctive expression and compartmentalisation differences between the deletion model and its wild-type …
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Expression levels of miRNA-127 in a cohort of HIV-positive and HIV-negative Diffuse Large B-Cell Lymphoma.
… be indicative of a poor outcome for patients. Micro-RNA(miRNA) are small non-coding RNA which can remain stable to be tested. There are several miRNAs which may be linked to prognosis, including miRNA-21 whose upregulated expression has been associated with bad prognosis. However, this is not …
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miRNA expressione profiles in retinal neurodegenerative diseases
I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …
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Genetic factors affecting the RNA interference pathway of Aedes aegypti mosquitoes
… cause tremendous social and economic impact. RNA interference (RNAi) plays a crucial role in the vector competence of mosquitoes and is often targeted in studies involving mosquito innate immunity, genetics-based vector control strategies, and the development of viral-resistant transgenic …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… protective decrease in fibrosis, we performed RNA sequencing on the NHCFs after hCBSC-derived exosome treatment. The group treated with both TGFβ and exosomes showed a decrease in micro RNA (miRNA) and small nucleolar RNA (snoRNA), known to be involved with ribosome stability. A 24hr I/R study …
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An investigation of mutant p53 function.
… were specifically examined through expression microarray analysis, which identified a number of mutant p53-regulated targets. Surprisingly, these targets were predominately also direct targets of wild-type p53. A novel mechanism for mutant p53 activity is subsequently suggested, whereby mutant …
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Dynamic changes of TDP-43 in testicular and epididymal sperm
… conserved protein. TDP-43 is a DNA/RNA binding protein with several functions such as gene transcription, mRNA splicing and stability, transposon silencing, and micro RNA biogenesis. TDP-43 is associated with many neurodegenerative disorders, including amyotrophic lateral sclerosis …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… These findings suggest that EV internalisation is at least partially required and that transcriptional changes may underlie the observed effects. Consistent with this hypothesis, inhibition of transcription with actinomycin D attenuated the full protective effect of MSC-EVs. A review …
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