Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"micro electrode array"”.
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Optimizing Multi-Well Micro-Electrode Array (MW-MEA) Design to Study the Electrophysiology of Neurons
Microelectrode arrays (MEAs) have been widely utilized to measure and study neuronal activities, both in vitro and in vivo. The main focus of this study was to optimize the MEA design to improve the recording efficiency from a group of cells in an area to have a better understanding of what is …
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Development and modelling of a versatile active micro-electrode array for high density in-vivo and in-vitro neural signal investigation
… small scale networks to be observed using arrays of micro-fabricated electrodes. These arrays transduce ionic perturbations local to the cell membrane in the extracellular fluid into small electrical signals within the metal that may be measured. A device was designed for optimal electrical …
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Characterization of spontaneous and evoked activity of mouse embryonic stem cell derived motor neurons using optogenetics and micro electrode array electrophysiology
… MN networks. The following work uses multi-electrode array (MEA) electrophysiology and optogenetics to characterize electrical activity of MNs differentiated from mouse embryonic stem (mES) cells. A customizable substrate integrated 60-electrode MEA chip was designed for this study. MEA …
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Advanced technologies for spatio-temporal control of neural circuits using optogenetics
… tool to exploit this possibility combining micro-electrode array (MEA) electrophysiological recordings with a custom two-photon microscope and optogenetic stimulation system based on a μLED array. This thesis reports on the construction, validation and application of this tool, that was …
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Ion flow and membrane tension studies with optical tweezers and nanopipettes
… experimental techniques into a single microscope setup and the studies this has enabled. Optical tweezers, nanopipettes, and fluorescence were all combined to study the effect of salt species on nanoscale voltage driven flows, the mechanical behaviour of cell membranes, and the …
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Neocortical functional network development at the microscale: impairments and mechanisms in Rett Syndrome.
… in studying brain network topology is that microscopic networks at the microscale cannot be studied noninvasively in humans. It is particularly challenging to study microscale networks during early development in animal models as the brain is rapidly changing in size. This could have …
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Engineering novel neuronal circuits using HI-PSCS derived neurons and microglia
… there might be a link to the emerging role of microglia in synaptic remodeling. However, it is still unclear as to what is the role of microglia during the development and refinement of the neuronal circuits in the brain. From previous in vivo studies, we know that microglia mediate the …
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IN SITU MEASUREMENT OF TRACE METALS IN COASTAL WATERS
… flow-through cells with a gelcoated Iridium (Ir) micro-electrode array have resulted in submersible in s/Yu voltammetric probes which allow long-term trace metal measurements at sub-nanomolar concentrations in coastal waters. Such In situ probes hold great promise for water quality monitoring. …