Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"mice model"”.
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
… <em>Col3a1<sup>+/-</sup> </em>mouse as an injury model, and the results confirm that <em>Col3a1<sup>+/-</sup> </em>mice have aberrant arterial injury repair. Arteries from the injured <em>Col3a1<sup>+/-</sup> </em>mice showed increased cell proliferation, inflammation, and neovessel formation. …
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Effects of 5-Lipoxygenase Activating Protein Inhibitor on Abnormal Alveolarization and Lung Development Induced by 85% Oxygen Exposure in Newborn Mice Model
배경: 미숙아에서 발병하는 기관지폐이형성증은 만성적인 호흡곤란과 산소의존도를 나타내는 질환으로서 인공환기요법, 고농도산소, 감염, 영양결핍, 수액과다공급 등의 다양한 원인으로 인한 염증성 반응과 비정상적 폐포화 과정 및 폐포 생성의 감소를 일으키는 것으로 알려져 있다. 최근 동물실험 연구에 의하면 신생 랫드에서 고농도 산소를 투여한 경우 비정상적 폐포생성을 초래하는데 이 과정에 leukotriene이 관여하는 것으로 보고되고 있다. 또한 치사 농도 이하의 농도인 85% 산소에 노출된 신생 마우스에서도 비정상적인 폐포화 현상이 …
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Multimodal imaging monitoring of key physiological changes of peripheral arterial disease
… an inadequate resemblance of the animals’ model to the actual disease in humans, and the complexity of the disease’s mechanisms. In this project, we utilized a type I diabetic mice model to establish a working platform that allows us and other researchers and scientists to standardize the …
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Discovery of bioactive peptides from amphibian skin secretion
… the biofilm of S. aureus and MRSA. Therefore, a mice model was used for evaluating its further in vivo antimicrobial activity. <br/><br/>In Chapter 4, a novel dermaseptin peptide, QUB-2522, was identified from the defensive skin secretion of the Northern orange-legged leaf frog, Phyllomedusa …
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Accumulation of perfluorooctanoic acid in intestine and lung tissues and its effect on gene expression across multiple pathways
… studies including epidemiological, animal model and invitro has linked PFOA to different organs toxicities. Although the gastrointestinal tract and lung tissues are primary organs exposed to PFOA, they are not well explored for its toxicities. Herein we utilized the CD1 male mice model to …
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… RPE and retained for a period of 21 days in I/R mice model. The relative retention of intravitreal and intravenous dendrimers was comparable, if a 30-fold intravenous dose is used; suggesting intravenous route targeting retinal diseases are possible with dendrimers. D-NAC when injected …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially diminished upon mutant KRAS (KRAS*) signaling blockade but recovered in tumor cells that bypass KRAS* dependency hence implicating its role underlying acquired resistance to KRAS* …
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… The amphiphiles exhibited Critical Micellar Concentration in the range of 7-30 μM. Transmission electron microscopy images revealed the formation of spherical micelles in the size range of 10-40 nm. Forster Resonance Energy Transfer studies revealed entrapment of hydrophobic dyes …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… formation and tumor progression in xenograft mice model. The ALDH+ cells were also resistant to 5-fluorouracil and radiation that is additionally augmented by both the lipid-mediators. Moreover the impact of lipid inflammatory mediators on the stemness properties of CICs was evident by …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… patients. Because, different from other animal models to mimic diseases with DNA repair protein deficiency, ATM-/- mice do not recapitulate the phenotypes of A-T patients, making it difficult to study the mechanism of neurological phenotypes of this disease in mice. To make the proper mice model …
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Effects of Trypanosoma brucei brucei on spatial learning and memory
… Studies on the Trypanosoma evansi infection mice model has shown that in addition to the sleep disorder caused by trypanosomiasis disease, learning and memory formation were impaired. Besides, only a little research has been conducted to validate this claim. Thus, this study aims to; i) …
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Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors
… to determine EC50 values. The U937 cell line and mice model were utilized for hit compounds to quantify S1P reduction in vitro and in vivo. Our preliminary results indicated compound 2.14d was the best hit discovered, with 88% SphK1 inhibition at 1 μM. In addition, compound 2.14d with a Ki of 0.68 …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
… this study, we employed two experimental animal models to study the role of IL-6 activation in the development and progression of aortic aneurysms. In an Ang II-treated C57BL/6 mice model, we tested the relationship of IL-6 signaling with Th17-induced inflammation in the formation of Ang …
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OPTIMIZATION OF AAV9 GENE THERAPY FOR SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS TYPE 1 USING IN VIVO DISEASE MODELS
… them intracerebroventricularly in SMARD1 mice model (nmd), during the presymptomatic phase of the disease at postnatal day 1. This comparison allowed us to determine which is the best construct to be translated to the clinic. Then, with the aim to precisely define the therapeutic window, …
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Spray Techniques And Lung Cancer Chemoprevention
… agents in lung tumorigenesis using the A/J mice model. The other is a twin-head electrospray: THES) to generate chemopreventive agent particles. Six single agents and three combinational agents, both natural and synthetic compounds, were investigated in the first part of this dissertation …
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Histological Changes in Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in a Photoaged Mouse Model
… the histological studies of PDT in animal model have rarely been reported. Objectives: I observed the histological changes in photoaged mouse skin specimens and in the specimens after photorejuvenation induced by 5-aminolevulinic acid (ALA)-PDT. Furthermore, I investigated transmission …
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Co-cultures and cell sheet engineering as relevant tools to improve the outcome of bone tissue engineering strategies
… a single osteogenic cell sheet in a nude mice model. Furthermore, in order to promote vascularization, co-cultured osteogenic cell sheets with endothelial cells were also created. Endothelial cells, stacked in between osteogenic cell sheets, were proven to contribute to new vessel …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… signaling using transgenic murine models. It was first noted that Foxp3+ Treg cells do express IL-4Rα under steady-state. Furthermore, in vitro, purified CD25+ Tregs were prompted to higher Foxp3 expression and increased survival upon stimulation with IL-4 arguing for a potentiating …
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Molecular Mechanisms of Itch Sensations
… responses to pruritogens. Because GRPR mutant mice still have remained itch responses, it is possible that additional itch mediators are present in the spinal GRPR neurons. Differential screening and pharmacological or small interfering RNA: siRNA) approach identified four …
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