Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 404 for “"miRNAs"”.
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Role of miRNAs in Oligodendrocyte Development
MicroRNAs (miRNAs) sind entscheidend für die Regulation von unterschiedlichen Prozessen in der Zellbiologie. Die Funktion von miRNAs im Zentralen Nervensystem (ZNS) und besonders in Gliazellen ist jedoch weitgehend unbekannt. Im ZNS werden Oligodendrozyten für die Myelinisierung der Axone benötigt. …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
<p><strong>The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… pathogenesis of different diseases. MicroRNAs (miRNAs) are small (18-25 nucleotide long) non-coding RNAs which play pivotal roles in the gene expression process and it is estimated that about one third of the human genome is controlled by miRNAs. miRNA regulatory processes have been found to …
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
… (2). Experiments characterizing the role of miRNAs in the developing cortex demonstrate the requirement of miRNAs for differentiation of neural progenitor cells starting at embryonic day 12.5 (3). Together, this evidence links the role of miRNAs to neurogenesis and thus this relationship …
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Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer
Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The …
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The Epstein-Barr Virus-Encoded BHRF1 miRNAs Regulate Viral Gene Expression in Cis
… is composed of three virally encoded primary miRNAs (pri-miRNAs) which are processed into four highly expressed mature ~22nt miRNAs that target mRNA for translational inhibition or degradation: miR-BHRF1-1, 1-2, 1-2*, and 1-3. Virally encoded miRNAs have been shown to enhance pathogenesis by …
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Biological Network-based Approaches to The Functional Analysis of miRNAs in Prostate Cancer
… miRNA research. This integration layer between miRNAs and protein networks helps to study the propagation of miRNAs’ influence through the biological networks of the targets. This thesis provides a profound review of the cross-talk between miRNAs and biological networks, particularly protein …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… suppressive properties: p21-induced senescence, miRNAs, and the DNA damage response. We found that E2F1 acts as a tumor suppressor in response to ras activation through a non-apoptotic mechanism requiring ARF and p53, but not p21. However, p21-loss inhibited two-stage chemical carcinogenesis in …
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Analysis of the involvement of exosomal miRNAs and proteins in the response of CRC cells to Cetuximab
Recentemente è stata dimostrata l’importanza della comunicazione intercellulare attraverso vescicole rilasciate dalle cellule sia a livello fisiologico sia a livello dello sviluppo e della progressione dei tumori, compresi l’angiogenesi ed i processi metastatici. La comunicazione cellulare può …
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Deletion plastidärer ribosomaler Proteine in Nicotiana tabacum im Kontext reduktiver Genomevolutionund Entwicklung einer Hochdurchsatzplattform zur Analysevon miRNAs in Chlamydomonas reinhardtii
… semiquantitativen Analyse von 192 verschiedenen miRNAs aus Chlamydomonas reinhardtii etabliert werden. Es gelang durch die Untersuchung von 23 verschiedenen Wachstums- und Stressbedingungen sowie Entwicklungsstadien mehrere miRNAs zu identifizieren, die eine differenzielle Expression zeigen sowie …
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Neuronal FMRP: facilitating learning in a critical brain network for zebra finch song acquisition and regulating synaptic miRNAs spatio-temporally
… translation regulation via the miRNA pathway. miRNAs are small, genomically-encoded RNAs that regulate translation of target mRNAs, generally by translation suppression of these target mRNAs. It is unknown how miRNAs are regulated in neurons both spatially and temporally. Studies in our and our …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… UGT1A8, UGT1A10 and SLCO4A1. We found 22/798 miRNAs to be differentially expressed under HU treatment, with the majority (13/22) being functionally associated with HbF-regulatory genes, including BCL11A (miR-148b-3p, miR-32-5p, miR-340-5p, miR-29c-3p), MYB (miR-105-5p), KLF-3 (miR-106b-5), and …
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DIAGNOSTIC APPROACH TO MYXOMATOUS MITRAL VALVE DISEASE IN CAVALIER KING CHARLES SPANIELS: IDENTIFICATION OF EARLY DIAGNOSTIC FACTORS (MORPHOMETRIC PARAMETERS AND MIRNAS EXPRESSION)
… for MMVD screening. By profiling salivary miRNAs associated with MMVD severity in CKCSs, we identified significant differential expression patterns across ACVIM stages, with specific miRNAs associated with disease presence and severity. Saliva-based profiling showed promising diagnostic …
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Gene expression and human oocyte maturation: transcriptional control and post-transcriptional mechanisms based on intercellular signalling via exosomal miRNAs in follicular microenvironment
Lo scopo di questa tesi è la caratterizzazione dei profili di espressione di mRNA e miRNA nel gamete femminile e nel suo microambiente, rispettivamente, in condizioni fisiologiche e non, al fine di i) valutare l'effetto della vitrificazione sul profilo biomolecolare degli ovociti, ii) comprendere …
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Studies of a restricted signature of circulating miRNAs as non-invasive biomarker in glioma: from the molecular function to the clinical application
… candidate as biomarkers. Several circulating miRNAs have been evaluated in gliomas as single biomarkers. However, it is widely recognized that single miRNA profiles may provide a low accuracy as cancer biomarkers, mostly due to the multifactorial nature of tumour and to the large number of …
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THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS
… several functions in RNA metabolism, including miRNAs biogenesis. Its accumulation within the ALS/FTD-associated cytoplasmic aggregates prevents it from performing these functions causing an alteration in miRNAs biogenesis and possibly a deregulation of miRNAs secreted by the affected cells …
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