Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"miRNA profiling"”.
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Implementation of global miRNA biomarker discovery in human plasma
… biomarkers. Small non-coding RNAs, specifically miRNAs, have been shown to exist extracellularly and are stable in biofluids, including blood and urine. The expression profile of extracellular miRNAs is also altered in a number of diseases making them attractive candidates for novel, non-invasive …
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CHARACTERIZATION OF PLACENTAL AUTOPHAGY AND BIOENERGETICS, AND MATERNAL MICRORNAS PROFILING IN OBESE PREGNANCIES AND GESTATIONAL DIABETES MELLITUS
… of 7 NW, 6 OB/GDM(-) and 6 OB/GDM(+), microRNA (miRNA) profiling in maternal plasma at delivery was performed with miRCURY LNA Serum/Plasma miRNA Focus PCR Panel (Qiagen). Statistical analysis and bioinformatics predictive tools: SPSS v.27 (IBM); GeneGlobe (Qiagen); miTALOS v.2; miRPath v.3. …
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The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
MiRNAs control skin homeostasis through post-transcriptional gene repression by binding to their target mRNAs. However, their role in regulation of apoptosis and hair loss in alopecia areata (AA) is largely unknown, which became the aim of this study. In AA mouse model (C3H/HeJ), global miRNA …
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… their potential as radiosensitizers. To identify miRNAs likely to be involved in influencing PCa radiation response, we first performed miRNA profiling analysis of PCa cell lines exposed to photon irradiation. Based on their modulation upon radiation exposure, and their role in regulating pathways …
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Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
… sample will need to be isolated to investigate miRNA or specific protein difference between groups; optimization of the protocol is required prior to further miRNA profiling and Western blot.</p> <p>This study demonstrated that there is a difference in the quantity and content of exosomes …
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The early zygotic genes and microRNAs in the yellow fever mosquito Aedes aegypti and the Asian malaria mosquito Anopheles stephensi
… strategies. As important gene regulators, miRNAs also play essential roles in early embryogenesis. The genome-wide predictions and systematic analysis of miRNAs in Ae. aegypti and Anopheles stephensi were conducted in this study. The first miRNA profiling in mosquito across all …
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Micrornas As A Therapeutic Target to Regulate Microglial Activation In Post Stroke Isolation In Aged Male Mice
… amyotrophic lateral sclerosis (ALS). MicroRNAs (miRNAs), a class of 18-25 nucleotide non-coding RNAs, have been shown to regulate the activation of microglia from a resting state to “disease-associated microglia (DAM)”. Preliminary work in the laboratory has shown post-stroke SI significantly …
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DIAGNOSTIC APPROACH TO MYXOMATOUS MITRAL VALVE DISEASE IN CAVALIER KING CHARLES SPANIELS: IDENTIFICATION OF EARLY DIAGNOSTIC FACTORS (MORPHOMETRIC PARAMETERS AND MIRNAS EXPRESSION)
… parameters with circulating microRNA (miRNA) expression. To accomplish this, three complementary studies were conducted, combining molecular, echocardiographic, and morphometric approaches to enhance the understanding of disease onset and progression. The first study was a prospective …
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Transcriptomic and Secretomic Profiling of Isolated Leukocytes Exposed to Alpha-Particle and Photon Radiation - Applications in Biodosimetry
… Although there has been an emergence of gene-profiling tools for the purpose of photon biodosimetry, similar capacities do not exist for alpha-particle radiation. Herein is the first genomic study useful for alpha-particle radiation biodosimetric triage. This work has identified robust …