Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"miRNA pathway"”.
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Neuronal FMRP: facilitating learning in a critical brain network for zebra finch song acquisition and regulating synaptic miRNAs spatio-temporally
… protein translation regulation via the microRNA (miRNA) pathway. Humans are vocal learners, meaning we must hear normal adult vocalization during a critical period in development in order to learn this vocalization properly. Because FXS has both impaired learning and atypical vocalization, it is …
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Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
… responsible for processing small RNAs in the miRNA pathway, have been shown to be interdependent in the C. elegans germline. The work described here is based on the hypothesis that if GLH-1 functions with DCR-1 in the miRNA pathway in the C. elegans germline, then when GLH-1 is missing or …
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Microrna-mediated regulation and the fragile X family of proteins
… post-translational modifications and microRNAs (miRNAs), respectively. Both proteins play key roles in normal development and function. The absence of FMRP leads to the cognitive defects seen in Fragile X syndrome, the leading cause of hereditary mental retardation, while loss of FXR1P expression …
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Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
<p>The cellular microRNA (miRNA) pathway has emerged as an important regulator of host-virus interactions. While miRNAs of viral and cellular origin have been demonstrated to modulate viral gene expression and host immune responses, reports detailing these activities in the context of mammalian …
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Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
… GSC factors to control CB differentiation pathway. In particular, studies of a key differentiation factor, bam, underscored the important paradigm of maintaining GSC by preventing the initiation of the CB differentiation pathway. The Dpp/BMP signaling pathway from the GSC niche promotes …
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Characterizing Populations of Non-Coding RNAs in <i>Karenia brevis</i> at Different Times of the Diel Cycle
… that the non-coding NATs, similar to microRNAs (miRNAs) in other organisms play a role in regulating gene expression. To test this prediction, I extracted total RNA from cells grown under different culture conditions, isolated and cloned the dsRNAs and miRNAs separately, and sequenced all …
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Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
… of the deadenylase complex (twin/CCR4) and the miRNA pathway (Argonaute 1) to control bouton formation. We propose that HPat is required to target mRNAs involved in the control of microtubule architecture and synaptic terminal growth for repression, presumably in P bodies, via both general and …
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Computational and experimental detection of uncoupling between transcriptome and translatome changes of gene expression
… proposed and the involvement of P-bodies and the miRNA pathway in post-transcriptional reprogramming of gene expression has been experimentally tested in the biological model of EGF induction, in order to explain how a change in translational fitness can counteract or magnify a parallel change in …
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Nuclear binding and translation regulation by FMRP through novel associated protein and putative RNA helicase MOV10
… of MOV10 acting as a facilitator or inhibitor of miRNA mediated regulation depending on proximity to Ago2 binding sites. Chapter 4 develops a novel single molecule study directed towards understanding how MOV10 behaves as a helicase. I generated mRNA constructs to study G quadruplex forming RNA …
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RNA helicase MOV10 is essential for gastrulation and normal CNS development
… its translational activity through the microRNA (miRNA) pathway. FMRP is critical for normal cognition and our findings hypothesize a role for Mov10 in brain function. Additionally, Mov10 has a well- documented role of protecting genomic integrity by suppressing actively transposing retroviral …