Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"miR-375"”.
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… that aberrant expression of microRNAs (miRs), a class of small non-coding regulatory RNAs, can be an important factor in prostate cancer metastasis. Previous studies in our laboratory identified serum miR-194 and miR-375 as novel markers of disease progression in men with PCa. However, …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… of DM is of paramount importance. MicroRNAs (miRNAs) have been shown to provide insight into both the biology and clinical behaviour of human cancers; hence, this thesis aims to characterize both the biological function and the prognostic utility of miRNAs in NPC.First, miR-375 was identified …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… to microRNAs, small RNA sequencing identified miR-375-3p as uniquely dysregulated in AD brains with concurrent infection. Functional enrichment of validated miR-375-3p targets revealed associations with vascular regulation, and antiviral response pathways, suggesting a role in maintaining …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
… staging. • Analysis of the expression levels of miR-143, miR-200c, miR-101, miR-34b and miR-375 microRNAs of all CRC patients compared to healthy colon tissue and correlation to RAS mutational status and according to patient staging. • Correlation between SIRT6, FOXO4, HIF3A genes and miR-143, …
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Identificazione di nuovi biomarcatori epigenetici per la diagnosi precoce del carcinoma colorettale
… di identificare computazionalmente un insieme di miRNA associati allo sviluppo e alla progressione del cancro del colon-retto al fine di convalidare il loro potenziale diagnostico e prognostico in una coorte pilota di pazienti con CRC e controlli sani. In particolare, è stata eseguita prima …
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… thesis I have investigated the role of Ca2+, miRNAs and rosuvastatin in the regulation of ion channels, exocytosis and insulin secretion of beta cells. For this purpose, pancreatic rat INS-1 832/13 beta cells, rodent animal models, and islets from human cadaver donors has been used. Whole-cell …
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Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions
… demonstrated the potential for microRNA (miR) in the serum to be used as a non-invasive prognostic factor for non-muscle invasive bladder cancers (NMIBC). With the help from a vast amount of miR profiles, we were able to identify two panels in overall population (miR-16/miR-378 + …
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NEW PREDICTIVE FACTORS IDENTIFIED BY MOLECULAR STUDY IN CHEMORESISTANT HUMAN AND CANINE MAMMARY CARCINOMA CELLS
… such as the presence of SNPs and CNVs in DNA and miRNAs dysregulation can be involved in CMTs and BC resistance. In human BC, several studies have investigated the genetic and epigenic mechanism of chemoresistance. However, little is known about this mechanism in CMTs development and progression. …
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Identificazione del pattern di espressione dei microRNA nei pazienti con cancro del colon-retto e sua modulazione favorevole dopo l'arricchimento del microbiota intestinale con i probiotici
… tra i fattori epigenetici, come i microRNA (miRNA) e il microbiota intestinale nei confronti del CRC non sono stati ancora completamente chiariti. Nell'ultimo decennio, diversi studi preclinici e clinici condotti utilizzando nuove tecnologie ad alto rendimento (ad esempio, metagenomica, …
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Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.
… after transplantation. In this study, I validate miR-375 and miR-200c as reliable biomarkers for measuring islet graft damage following total pancreatectomy with islet autologous transplantation. I then demonstrate a reduction in these biomarkers and decreases in immune cell activation through …
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Theoretical and Computational Studies on the Dynamics and Regulation of Cell Phenotypic Transitions
… KSRP, which repress each other through microRNAs miR-375 and miR-135a. The motif can generate switch behavior and serve as a noise filter in the stem cell differentiation process. Manipulating the motif could enhance the differentiation efficiency toward a specific lineage one desires. Last we …