Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"miR-34a"”.
-
The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy
… the biologic effects of overexpression of miR-34a, a tumor suppressive microRNA that downregulates multiple proteins involved in PCa progression. I demonstrated that miR-34a is downregulated in high metastatic PCa cell lines, concomitant with its targets being overexpressed. Overexpression …
-
Microrna Regulation of Prostate Cancer Stem/Progenitor Cells and Prostate Cancer Development
… therapeutics. Recent discoveries of microRNA (miRNA) have provided a new avenue in understanding the regulatory mechanisms of cancer. However, how miRNAs may regulate CSCs is still poorly understood. Here, we present miRNA expression profiling in six populations of prostate cancer (PCa) …
-
Axl RTK and microRNAs in urogenital cancers
… Importantly, we identified a 2-microRNA ratio, miR(21/10b), which is an independent prognostic factor in metastasis-free ccRCC patients. These microRNAs are both linked to chronic kidney disease, a risk factor for ccRCC, and could potentially be involved in the progression from kidney disease to …
-
Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… of Farnesoid X receptor (FXR) and microRNA-34 (miR-34a), as key transcriptional and post-transcriptional regulators respectively, in maintaining metabolic hemostasis and energy balance. Nuclear receptors (NRs) are lipophilic ligand-dependent transcriptional factors that regulate the expression …
-
Identification of Circulating MicroRNAs as Biomarkers in Glioblastoma
MicroRNAs (miRNAs) are small RNA sequences 22-25 nucleotides in length which play a role in post-transcriptional gene regulation by binding to target mRNA sequences preventing translation. Changes in miRNA expression can contribute to disease pathogenesis, including gliomagenesis. The release of …
-
Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… this question, I analyzed FXR regulation of miRNAs by gene array analysis and binding of FXR genome-wide by ChIP-seq studies. FXR regulates many target genes in the liver in different metabolic pathways. It is not clear how this is accomplished, but one possibility is that FXR regulates …
-
Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… mainly focusing in non-coding microRNAs (miRNA) epigenetics control. Results showed that proadipogenic miRNAs were controlling metabolism of LM of NW-MPN steers between 78 and 187 days of age through activation of: a) miR-103 that inhibits CAV1 that destabilizes INSR increasing insulin …
-
miRNA expressione profiles in retinal neurodegenerative diseases
I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …
-
Intervention of non-small cell line cancer oncogenic pathways with delta-tocotrienol
… delta-tocotrienol is a non-toxic activator of miR-34a which can inhibit NSCLC cell proliferation, induce apoptosis, and inhibit invasion. Last but not the least, We observed that delta-tocotrienol individually or in combination with cisplatin exhibited potent anticancer abilities in NSCLC cells …
-
Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… its role regulating microRNAs, in this case, miR-98 and miR-34a, which in turn regulate known EMT transcription factors Twist1 and Lef1. Alterations of ΔNp63 led to the development of various tumor types, among them mammary adenocarcinomas that were aggressive and highly metastatic. Focusing …
-
Negative regulation of gene expression by the tumor suppressor p53
… categories: proteins (e.g. p21), microRNAs (e.g. miR-34a), and lincRNAs (lincRNA-p21). This dissertation discusses multiple aspects of p53-dependent gene repression and presents novel targets of p53-mediated regulation. Specifically, we have found that p53 down-regulates the transcription of the …
-
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
… deleterious expression patterns for miR-124, miR-132, and miR-34a, critical to homeostatic neuroimmune maturation, were observed in Pb-exposed Tg females by PND 10 and 21, suggesting persistent, epigenetic re-patterning of the microglial response phenotype and limited adaptability. …
-
Molecular pathways controlling DNA damage response
… between p53 protein and its co-factor (TTC5). MiRNA-34 family members that are transcriptional p53 targets were also investigated in studied cancer cell lines. Decrease in the miR-34a expression was observed in treated A549, Mero-25, and Mero-14 cancer cells compared to untreated cells, whereas …
-
The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… We profiled the expression of SC microRNAs: miRNAs) after peripheral nerve lesions as well as characterized the injury response of SCs with disrupted miRNA processing and showed that SC miRNAs modulated the injury response largely by targeting positive regulators of SC …