Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"miR-34"”.
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The Expression of the Transcription Factor Broad and RNA-Binding Factors in the Midgut of the Mosquito Aedes Aegypti During Metamorphosis
… and correlated its expression with that of nine miRNAs and three RNA-binding factors. During midgut metamorphosis the expression of these factors was dynamic and reproducible.</p> <p>To better understand the changes in expression patterns, I evaluated the effects of hormone analogs on expression. …
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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer
… is known about their regulation by microRNAs (miRNAs). miRNAs are small, non-coding, endogenous RNAs that are transcribed, processed, and used to direct cellular proteins that destabilize or block translation of target mRNA. In this study, we first sought to determine the miRNAs that are …
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The E2F1-responsive microRNA-449 promotes apoptosis
… Microarray-Hybridisierung durchgeführt, und fand miR-449a und miR-449b (zusammen miR-449 genannt) stark durch E2F1 induziert. MiR-449 und sein Host-Gen CDC20B sind nach E2F1-Überexpression und nach DNA-Schädigung stark erhöht. Interessanterweise sind die Seed -Sequenzen und Zielgene von miR-449 …
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Axl RTK and microRNAs in urogenital cancers
… Importantly, we identified a 2-microRNA ratio, miR(21/10b), which is an independent prognostic factor in metastasis-free ccRCC patients. These microRNAs are both linked to chronic kidney disease, a risk factor for ccRCC, and could potentially be involved in the progression from kidney disease to …
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Microrna Regulation of Prostate Cancer Stem/Progenitor Cells and Prostate Cancer Development
… therapeutics. Recent discoveries of microRNA (miRNA) have provided a new avenue in understanding the regulatory mechanisms of cancer. However, how miRNAs may regulate CSCs is still poorly understood. Here, we present miRNA expression profiling in six populations of prostate cancer (PCa) …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… EMT/MET – interconnected feedback loops among miR-34, miR-200, ZEB, SNAIL families – to predict that it can act as a ‘three-way’ switch enabling three phenotypes – epithelial (high miR-200, low ZEB), mesenchymal (low miR-200, high ZEB) and hybrid E/M (medium miR-200, medium ZEB). Second, GRHL2 …