Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"miR-335"”.
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ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
… role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but downregulated in AD. miR-335 overexpression in cultured basal keratinocytes resulted in increased expression of keratinocyte differentiation markers and cornified …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 suppressed metastasis through inhibition of cell-autonomous metastatic phenotypes of cell migration and invasion, the role of miR-126 in metastasis remained unknown. Here, endogenous miR-126 is shown to …
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… thesis I have investigated the role of Ca2+, miRNAs and rosuvastatin in the regulation of ion channels, exocytosis and insulin secretion of beta cells. For this purpose, pancreatic rat INS-1 832/13 beta cells, rodent animal models, and islets from human cadaver donors has been used. Whole-cell …
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A Network Approach to Understanding miRNA Regulation in Adipose Tissue
… we employ two contrasting approaches to identify miRNAs that influence adipocyte phenotype. First, miRNAs were sequenced from 6 fat pads, primary preadipocytes, and primary mature adipocytes. Comparative analyses of abundance across adipose tissue type and stage of differentiation revealed a …
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RNA Deregulation in Metastatic Breast Cancer
… mRNA in complex with small non-coding microRNAs (miRNAs), HITSCLIP derived 3'UTR binding sites have been shown to correspond to sites of functional miRNA-mediated target down regulation. In this study, a molecularly characterized cell culture based model system of breast cancer metastasis has been …
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Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis
… as putative targets of the metastasis suppressor miRNAs, miR-126 and miR- 335. We identify PITPNC1 as amplified in nearly half human breast cancers, and overexpressed in metastatic melanoma, breast, and colon cancer. Biochemical and cellbiological experiments reveal that PITPNC1 binds to …
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Investigating the molecular mechanisms of the metabolic syndrome
… The same liver samples were hybridised to a miRNA array. Two miRNAs showed a nearly 2-fold upregulation in the UN livers. Both were found to be either directly or indirectly associated with the metabolic syndrome. MiR-335 has been shown to be upregulated in the livers of obese/diabetic mice. …
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I MICRORNA NELLE DISTROFIE MIOTONICHE
… of an RNA gain of toxic function. MicroRNAs (miRNAs) are short non-coding RNAs (~22 nucleotides) regulating gene expression post-trascriptionally either via the degradation of target mRNAs or the inhibition of protein translation. MicroRNAs have been shown to be involved in a range of …