Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"miR-290"”.
-
The role of mir-290-295 in murine embryonic and germ cell development
… of every biological process known to date. Mir-290 through mir-295 (mir-290-295) is a mammalian-specific miRNA cluster that, in the mouse, is expressed specifically in early embryos and embryonic germ cells. This thesis examines the in vivo consequences of targeted deletion of mir-290-295 in …
-
MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse
… of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during early development. In this thesis, I have examined the role of a family of miRNAs, miR-290 through miR-295 (miR-290 cluster), which are specifically expressed …
-
Discovery of miRNA-regulated processes in mammalian development
… of non-coding ~22nt RNAs termed "microRNAs" (miRNAs). These RNAs guide the sequence-specific inhibition of translation and destabilization of mRNA targets through short (6-7 nucleotide) stretches of complementarity between the 5' end of the miRNA (seed region) and the 3' untranslated region …
-
The functional microRNA landscape of mammalian development
MicroRNAs (miRNAs) constitute a class of ~22 nucleotide RNAs with broad regulatory roles in gene expression. Dependent largely on the enzyme Dicer for their generation from longer precursor transcripts, mammalian miRNAs direct posttranscriptional repression of mRNAs based on complementarity to …
-
microRNA expression profile of undifferentiated and differentiating pluripotent cells
… Stammzellen) in der Maus. Dazu wurden globale miRNA Array Expressionsprofile von nicht differenzierten und differenzierten ESCs und maGSCs auf 129/Sv Hintergrund (die differenzierten Zellen wurden 21 Tage unter Konditionen, die die Differenzierung induzieren, kultiviert) analysiert. …
-
Modulation of Ago-miRNA regulatory networks by cis-sequence elements and target competition
… of organisms and biological processes. Each miRNA guides Argonaute (Ago) protein complexes to target and repress hundreds of genes in a sequence-dependent manner. To identify all targets of miRNA regulation, we performed UV crosslinking and immunoprecipitation (CLIP) of Ago complexes in mouse …
-
MicroRNA Expression Profiling of Multipotent Adult Germline Stem Cells
… RNAs identifiziert, die sogenannte microRNAs (miRNAs), die eine Schlüsselrolle in der embryonalen Entwicklung und Pluripotenz von Embryonalen Stammzellen (ESCs) spielen. Das Ziel dieser Arbeit war es, Ähnlichkeiten und Unterschiede zwischen maGSCs und ESCs im Bezug auf miRNAs zu untersuchen. …