Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"miR-221"”.
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The Functions of Setd5 and Mir-221 In Embryonic Stem Cell Differentiation
… a related but independent study, we show that miR-221-3p and miR-221-5p, which are encoded by the <em>miR-221</em> gene, are new anti-stemness miRNAs whose expression levels in mouse ESCs are directly repressed by the epigenetic modifier and pluripotent factor PRMT7. Notably, both miR-221-3p …
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Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in treating diseases such as cancer and arthritis, but there is no exosome or miRNA product yet available …
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MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
… enough for asymptomatic patients. MicroRNAs (miRs/miRNAs) are small non-encoding RNA molecules, which have been related with PDAC progression and metastasis. In particular, miR-21, miR-221, miR-155 and miR-126 have to date been shown to be highly dysregulated in human malignancies including …
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Analyzing the functions of human polynucleotide phosphorylase (hPNPaseold-35)
… agent due to its ability to degrade specific miRNA (miR-221) and mRNA (c-myc) species, and this property can be exploited in treating malignancies that are characterized by upregulation of harmful miRNA or mRNA molecules. But apart from these two targets, little is known about any other …
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Regulation of Mammary Gland Development and Tumorigenesis By 14-3-3 Zeta
… MAPK/c-Jun signaling leading to increased miR-221 transcription, which inhibited p27 translation, resulting in increased cell proliferation. Importantly, this 14-3-3z/miR-221/p27/proliferation axis also functions in patients' breast tumors and associates with high-grade cancers. While …
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Ο ρόλος της Γενετικής και Επιγενετικής ρύθμισης με microRNA στην παιδική παχυσαρκία
… σε παιδιά με παχυσαρκία. MicroRNA όπως τα miR-26b, miR-122, miR-145 και miR-221 συσχετίστηκαν με την λιπογένεση και τον ηπατικό μεταβολισμό, ενώ τα miR-146a, miR-223 και miR-486 συνδέθηκαν με δείκτες συστηματικής φλεγμονής. Επιγενετικές αλλαγές, όπως τροποποιήσεις στη μεθυλίωση περιοχών που …
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NEW FINDINGS INTO TARGET-DIRECTED MICRORNA DEGRADATION MECHANISM
MiRNAs are a class of small non-coding RNAs that function in post-transcriptional gene silencing by interacting with target RNAs. A novel mechanism in control of miRNA levels, called Target-Directed miRNA degradation (TDMD), has been described, which involves specific transcripts able to interact …