NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 29 for “"miR-21"”.

  1. Investigating the role of miR-21 in autophagy and VMP1

    O'Leary, Kate MarieThe University of Edinburgh2017

    … methylated region (DMR) around the miR-21/VMP1 locus in IBD patients compared to HC and elevated levels of VMP1 and miR-21 have been detected in patients. MiR-21 is a microRNA that is associated with immune related disorders, and VMP1 Is a key regulator of autophagy, a pathway …

    edinburgh Repository record

  2. Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus

    Sims, Emily K.2018

    The role of beta cell miR-21 in Type 1 Diabetes (T1D) pathophysiology has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in T1D and the phenotype of beta cell miR-21 overexpression through target identification. Furthermore, we sought to identify whether …

    iupui Repository record

  3. RESVERATROL INHIBITS PROSTATE CANCER GROWTH AND METASTASIS BY TARGETING AKT/MICRORNA-21 PATHWAY

    Sheth, Sandeep

    … for metastatic prostate cancer. MicroRNAs (miRNAs) are small (18~23 nucleotide long) non-coding RNAs that can influence gene expression by binding to the 3'-untranslated region of coding RNAs at the post-transcriptional level. Some miRNAs has been termed as oncomirs due to their role in …

    siu-theses Repository record

  4. Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6

    Sawant, Deepali Vijay2014

    … an intrinsic increase in Th2 genes and microRNA-21 (miR-21) expression. MiR-21 is a novel Bcl6 gene target in T cells and ectopic expression of miR-21 directs Th2 differentiation in non-polarized T cells. MiR-21 is up-regulated in mouse models of airway inflammation and also in human patients …

    iupui Repository record

  5. The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)

    Abderahman, Sama'Queen's University Belfast2020

    … effects were associatedwith a reduction in miR-21 levels (p < 0.05). To verify this association, the miR-21 expression was inhibited using an anti-miR-21 transient transfection assay. Data showed a significant upregulation of the anti-tumour mediators (CXCL10, p < 0.01). MicroRNA-21 …

    qu-belfast Repository record

  6. Connective Tissue Growth Factor in Pancreatitis

    Charrier, AlyssaThe Ohio State University2013

    … associated with enhanced expression of microRNA-21 (miR-21). A positive feedback loop between CTGF/CCN2 and miR-21 was identified that resulted in an enhancement of their respective expression as well as that of collagen 1a(I). Both miR-21 and CTGF/CCN2 mRNA were detected in nano-sized exosomes …

    ohiolink Repository record

  7. microRNA-21 as a Pro-Fibrotic Mediator in Right Ventricular Failure

    Powers, JefferyTemple University. Libraries2016

    … understanding of RV pathophysiology. microRNAs (miRs) are major post-transcriptional regulators and their altered expression has been implicated in several cardiovascular pathologies. We hypothesized that altered miR expression specific to the failing RV may underlie the molecular pathophysiology …

    temple Repository record

  8. MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy

    Mortoglou, MariaUniversity of Westminster2024

    … enough for asymptomatic patients. MicroRNAs (miRs/miRNAs) are small non-encoding RNA molecules, which have been related with PDAC progression and metastasis. In particular, miR-21, miR-221, miR-155 and miR-126 have to date been shown to be highly dysregulated in human malignancies including …

    westminster Repository record

  9. Identificazione di nuovi biomarcatori epigenetici per la diagnosi precoce del carcinoma colorettale

    MANNINO, MAURIZIOUniversità degli studi di Catania2021

    … di identificare computazionalmente un insieme di miRNA associati allo sviluppo e alla progressione del cancro del colon-retto al fine di convalidare il loro potenziale diagnostico e prognostico in una coorte pilota di pazienti con CRC e controlli sani. In particolare, è stata eseguita prima …

    catania Repository record

  10. Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells

    Shah, Maitri YogenEast Carolina University2010

    … 5-FU treatment. We hypothesized that microRNAs (miRNAs), the newly identified class of small regulatory RNAs, might play a mediator role in inducing the cytotoxicity of 5-FU, by regulating the expression of its target genes. Using a combined advanced microarray and quantitative real time PCR …

    ecu Repository record

  11. Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.

    Ahmed, Mohammed I.University of Bradford2011

    … of gene activation and silencing. MicroRNAs (miRNAs) are critically important for gene silencing and delineating their role in hair cycle may provide new insights into mechanisms of hair growth control and epithelial tissue remodelling. The aims of this study were: 1) To define changes in the …

    bradford Repository record

  12. MiRNA-Mediated Regulation of Colorectal Tumorigenesis

    Moore, Ashleigh Eleanor

    … lead to the development of cancer. MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as essential mediators of post-transcriptional gene regulation and are being increasingly recognized for their role in cancer. MiRNA expression is dysregulated in colon cancer and these changes in …

    south-carolina Repository record

  13. Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma

    Nguyen, Tran, <p><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__orcid.org_0000-2D0003-2D1219-2D1089&d=DwMCAA&c=6vgNTiRn9_pqCD9hKx9JgXN1VapJQ8JVoF8oWH1AgfQ&r=FA4hKPYMu6FBNFJuunCk4vEuQgh55eF_5pdLIdVc4o4&m=2FsrimFlbJYGxt4iuisFAMJ6npQq_9NKtAmMa_WM5gc&s=gWmMxmroFqqQnOVHYZosko5u-ycaaJicfxY3jBJTY3A&e=" target="_blank">0000-0003-1219-1089</a></p>2019

    … we perform integrated analyses of RNA-seq and miR-seq on 3 datasets: (1) UV-unexposed and acute UV-exposed human skin, (2) public dataset on acute wound healing and (3) our previously published dataset on normal skin and cuSCC from humans. We find that biological signatures and processes …

    uthsc Repository record

  14. Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions

    LIN, SHU-HONG, <p>https://orcid.org/0000-0002-4020-7714</p>2019

    … demonstrated the potential for microRNA (miR) in the serum to be used as a non-invasive prognostic factor for non-muscle invasive bladder cancers (NMIBC). With the help from a vast amount of miR profiles, we were able to identify two panels in overall population (miR-16/miR-378 + …

    uthsc Repository record

  15. EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS

    GENEVIEVE SAW TSE JING2020

    … pathway is epigenetically regulated through miRNA targeting by miR-21-5p and histone modifications via HDAC3 resulting in changes in PI3K expression, the phosphorylation of AKT and the cAMP response element binding protein (CREB) and ultimately brain-derived neurotrophic factor (BDNF) …

    nus Repository record

  16. miRNA expressione profiles in retinal neurodegenerative diseases

    ROMANO, GIOVANNI LUCAUniversità degli studi di Catania2017

    I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …

    catania Repository record

  17. Identificazione del pattern di espressione dei microRNA nei pazienti con cancro del colon-retto e sua modulazione favorevole dopo l'arricchimento del microbiota intestinale con i probiotici

    GATTUSO, GIUSEPPEUniversità degli studi di Catania2022

    … tra i fattori epigenetici, come i microRNA (miRNA) e il microbiota intestinale nei confronti del CRC non sono stati ancora completamente chiariti. Nell'ultimo decennio, diversi studi preclinici e clinici condotti utilizzando nuove tecnologie ad alto rendimento (ad esempio, metagenomica, …

    catania Repository record

  18. Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy

    Monroig, Paloma del C.2016

    <p><strong>The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …

    uthsc Repository record

  19. Identification and evaluation of novel biomarkers in diabetic kidney disease

    Zang, JinnanQueen's University Belfast2020

    … for the early detection of DKD. microRNAs (miRNAs) are short, non-coding regulatory ribonucleic acid (RNA) molecules that are commonly found in bio fluids and may reflect differential gene expression ongoing in the kidney during the disease process. Emerging evidence has shown that systemic …

    qu-belfast Repository record

  20. Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging

    Lin, Te-Yueh2022

    … anti-inflammatory role partially by regulating miR-21 expression and secretion in brown adipocytes. In the second project, we explored PTX3 secretion from adipose tissue and adipocyte and found that PTX3 is secreted mainly through conventional protein secretion, while a small percentage of PTX3 …

    umn Repository record

Page 1 of 2