Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"miR-205"”.
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and ZEB2. p53, the homologue of p63, is implicated in regulating EMT by modulating the expression of miR-200c; however, the mechanisms underlying miR-205 control remain …
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Micrornas That Affect Breast Cancer Growth, Metastasis And Estrogen-Independent Growth
TITLE of PART I: MICRORNA-205 IS A TUMOR SUPPRESSOR IN BREAST CANCER Major Professor: Dr. Yinyuan Mo MicroRNAs as a class of novel negative regulators have drawn intensive attention since their existence in mammals was discovered in 2001. As endogenous small non-coding RNAs, miRNAs are capable of …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… initiate the involutionary response. MicroRNAs (miRs) are small non-coding RNAs ~18-22 nucleotides in length that maintain cellular homeostasis and regulate stress responses. Previous work in the laboratory identified several microRNAs involved in regulating thymocyte responses to stress. …
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… their potential as radiosensitizers. To identify miRNAs likely to be involved in influencing PCa radiation response, we first performed miRNA profiling analysis of PCa cell lines exposed to photon irradiation. Based on their modulation upon radiation exposure, and their role in regulating pathways …
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Investigation of key non-coding and coding genes in cutaneous melanomagenesis
… been investigated in this thesis. microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotides in length that are found in both animal and plant cells. miRNAs are involved in the RNA interference (RNAi) machinery to regulate gene expression posttranscriptionally. miRNAs have …
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Novel Regulators of Somatic Cell Reprogramming
… was linked to BMP-dependent induction of miR-205 and the miR-200 family of microRNAs. These studies thus defined a multi-step mechanism that incorporates a BMP-miRNA-MET axis during somatic cell reprogramming. Next I focused on the two later phases of reprogramming, maturation and …