Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"miR-17-92"”.
-
Role of miRNAs in Oligodendrocyte Development
MicroRNAs (miRNAs) sind entscheidend für die Regulation von unterschiedlichen Prozessen in der Zellbiologie. Die Funktion von miRNAs im Zentralen Nervensystem (ZNS) und besonders in Gliazellen ist jedoch weitgehend unbekannt. Im ZNS werden Oligodendrozyten für die Myelinisierung der Axone benötigt. …
-
Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… organogenesis to occur. Members of the <em>miR-17-92 </em>cluster downregulate <em>Tbx1 </em>in cardiac progenitor cells to permit cardiomyocyte differentiation, and we demonstrated that members of this cluster are expressed in the 3<sup>rd</sup> pp endoderm and mesenchyme. We find that …
-
Discovery of miRNA-regulated processes in mammalian development
… of non-coding ~22nt RNAs termed "microRNAs" (miRNAs). These RNAs guide the sequence-specific inhibition of translation and destabilization of mRNA targets through short (6-7 nucleotide) stretches of complementarity between the 5' end of the miRNA (seed region) and the 3' untranslated region …
-
Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
… tumours have elevated expression of the miR-17-92 cluster of miRNAs. High-throughput proteomic analysis of miR-17-92 overexpressing cells revealed enrichemnt of the TGF-β pathway. Further analyses showed miR-17-92 targeted inhibition of the TGF-β pathway at multiple levels, resulting in …
-
microRNA expression profile of undifferentiated and differentiating pluripotent cells
… Stammzellen) in der Maus. Dazu wurden globale miRNA Array Expressionsprofile von nicht differenzierten und differenzierten ESCs und maGSCs auf 129/Sv Hintergrund (die differenzierten Zellen wurden 21 Tage unter Konditionen, die die Differenzierung induzieren, kultiviert) analysiert. …
-
MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
… and interplays between two emerging mechanisms, miRNAs and epigenetic processes, in regulating CD4+ T cell-mediated responses. Using both gain- and loss-of-function genetic tools, we demonstrated that a miRNA cluster, miR-17-92, is critical to promote Th1 responses and suppress inducible Treg …
-
Identifying Context-Specific Synthetic Lethal miRNA Inhibition in Non-Small Cell Lung Cancer
… regulators, to identify novel synthetic lethal miRNA inhibition:molecular mechanism interactions in NSCLC. I accomplished this by screening a panel of 13 NSCLC and immortalized normal lung epithelium (HBEC) cell lines in two phases to identify miRNA inhibitors with selective toxicity in the …
-
Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… revealed significant decreases of members of the miR-17-92 and miR-106b-25 clusters, which are upregulated in PCa and have been shown to be involved in cell survival and tumor progression. Mechanistic studies in cultured mouse and human PCa cell lines further confirm the pleiotropic effects of the …