Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"miR-155"”.
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
… risk of developing cancer.</p><p>Micro-RNAs (miRNAs) regulate numerous cellular functions. MiRNA genes are transcribed as long primary (pri-miRNA) transcripts that are subsequently 'cropped' by the Drosha/Dgcr8 complex into precursor miRNAs (pre-miRNA) that have a characteristic stem-loop …
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Role of microRNA-155 in dendritic cells and macrophages: MiR-155 directly targets PU.1 and IL13Rα1
… or pro-tolerogenic) macrophages, BIC (microRNA 155 hosting gene) was found up regulated under inflammatory conditions. MicroRNAs are non coding RNAs of ~22nt in length that inhibit gene expression upon pairing to the 3’UTR (UnTranslated Region) of target mRNAs. <i>In silico </i>analysis …
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MicroRNA as Regulator of the Th17 Inflammation in Behcet's disease
BACKGROUND: MicroRNAs (miRNAs) play a critical role in the regulation of host genomic expression; they are also involved in regulation of the immune response by control of target genes. Recent studies of miRNAs have revealed that aberrant expression and/or function of miRNAs in chronic inflammatory …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… disease with no adequate therapies. MicroRNAs (miRNAs) are dysregulated in a variety of disease states, suggesting that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA changes in ALS model SOD1G93A rodents identified 12 miRNAs as …
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Regulation of Immunoglobulin Gene Diversification By Noncoding RNA's
… (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeatassociated small RNAs. Here, I describe the contribution of miRNA-mediated regulation to a specific case of gene expression that requires significant somatic alteration of the genetic code. B …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
Micro-RNAs (miRNAs) are a class of non-coding RNA which post-transcriptionally regulate gene expression. Epstein-Barr Virus (EBV) transforms resting B-cells in vitro to establish continuously proliferating lymphoblastoid cell lines (LCLs) and is aetiologically linked to lymphomas. Little is known …
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An investigation of mutant p53 function.
… relationship between mutant p53 and a micro-RNA (miR-155) established. Mutant p53 expression is shown to correlate with miR-155 expression, with miR-155 target genes involved in invasive pathways. ZNF652 is specifically identified as a target of miR-155 and loss of ZNF-652 is correlated with …
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Endotoxin-induced microRNA expression in equine peripheral blood mononuclear cells
… neonatal sepsis and other diseases. MicroRNAs (miRNAs), small non-coding RNA molecules acting as post-transcriptional regulators of gene expression, have key roles in TLR4 signaling regulation in other species. The central hypothesis of this study was that LPS induces differential expression of …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… investigated the potential role of microRNAs (miRNAs) in AID mediated processes. MiRNAs are small non-coding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA in vivo we created a knock-in mouse that carries a …
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A study of mammalian microRNA-mediated repression of gene expression by ribosome profiling
… well as post-transcriptional, level. MicroRNAs (miRNAs) are -22- nucleotide small RNAs that mediate post-transcriptional regulation of gene expression by base pairing to their target mRNAs to direct repression. In animals, this repression is usually mediated through translational repression …
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MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
… enough for asymptomatic patients. MicroRNAs (miRs/miRNAs) are small non-encoding RNA molecules, which have been related with PDAC progression and metastasis. In particular, miR-21, miR-221, miR-155 and miR-126 have to date been shown to be highly dysregulated in human malignancies including …
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Investigations into the molecular regulation of gene expression in airway smooth muscle cells
… and asthmatic individuals.<br/>microRNAs (miRNAs) are short, non-coding RNAs that exert a post-transcriptional regulation on gene expression by targeting specific mRNAs for down regulation through either mRNA degradation or translational repression. During this project microarray studies …
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High-throughput sequencing of RNA 5'- and 3'-termini yields insights into viral and vertebrate gene expression
… The isoform ratios of transcripts containing miR-155 sites were predictive of the extent to which these transcripts would respond to miR-155 transfection. Conversely, knocking out miR-22 in mice specifically upregulated isoforms containing miR-22 sites, suggesting that microRNAs reciprocally …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… and/or aberrantly expressed microRNAs (miRNAs).</p> <p><strong>Material and methods: </strong>In 42 PDAC tumors, the <em>SEL1L</em> coding region was amplified using reverse transcription polymerase chain reaction (RT-PCR), and analyzed by agarose gel electrophoresis and sequenced to …
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miRNA expressione profiles in retinal neurodegenerative diseases
I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …
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Ο ρόλος των κυκλοφορούντων miRNA ως προγνωστικοί βιοδείκτες στην ανάπτυξη και τη θνητότητα του Συνδρόμου Οξείας Αναπνευστικής Δυσχέρειας (ARDS)
… ανασκόπηση των μελετών που αφορούν τη μελέτη των miRNA στο πλάσμα ασθενών με ARDS και τη χρησιμότητά τους στη διάγνωση και την πρόγνωση του νοσήματος. Αποτελέσματα Συνολικά, από τις 438 μελέτες που ελέγχθηκαν, 33 εξ αυτών συμπεριλήφθηκαν στη συστηματική ανασκόπηση. Όλες οι μελέτες ήταν προοπτικές …
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Co-régulation de Pax-5 et des microarns dans le cancer du sein
… dans le cancer du sein. On démontre que les miR-484 et MiR-210 sont dérégulés dans le cancer du sein et ceux-ci portent la capacité de réguler Pax-5 et ses effets phénotypiiques associés de façon directe. De plus, on démontre par séquençage à haut-débit que plusieurs miARNs sont …
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Molecular regulation of glioma cell migration: assessment and therapeutic implications
Molecular regulation of glioma cell migration: assessment and therapeutic implications Florian Gessler Glioblastomas are among of the most aggressive human tumour types. Overall survival in patients with this malignancy is no longer than 18 months despite receiving extensive therapy. The …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. We used the non-obese diabetic mouse (NOD) which is spontaneously developing T1D and have been described to have defects in the T cell maturation. By studying the …
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