Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"miR-145"”.
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression at the post-transcriptional level by interacting with the 3'-untranslated region (3'-UTR) of a target gene. Our previous studies indicate that miR-145 is downregulated in breast and colon cancer; moreover, it functions as a …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… pathway in pancreatic cancer.</p> <p>MicroRNAs (miRNA) have been identified as attractive targets for therapeutic intervention. The functional significance of lost miRNAs have been reported in several human malignancies, including PanCa. Restitution of lost miRNA function can provide a potential …
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The development and characterisation of MicroRNA and gemcitabine nanotherapies for the treatment of pancreatic cancer
… expression of targeted genes. The utilization of miRNAs as therapeutic agents has showed promising rapid progress in the last 10 years but are limited because of the lack of appropriate delivery systems that will ensure reach of the pharmacological targets. On the other hand, the bottleneck with …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… and can cause relapses. MicroRNAs (miRNAs) can act as regulators of CSCs, by controlling stemness and invasion. We postulate that PEBP or its polyphenolic components induce specific epigenetic changes by modulating miRNA networks, reducing CSCs, and preventing breast carcinoma. Thus, …
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Characterization of Inducible SMC-specific Drosha Knockout Mice
… cells. Recent studies have shown that microRNAs (miRNAs), a new class of small RNAs that function as guide molecules in RNA silencing, regulate and maintain the differentiation state of SMCs. A transgenic animal model to study SMC-specific knockout of Dicer, one of two RNase III proteins in miRNA …
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Ο ρόλος της Γενετικής και Επιγενετικής ρύθμισης με microRNA στην παιδική παχυσαρκία
… σε παιδιά με παχυσαρκία. MicroRNA όπως τα miR-26b, miR-122, miR-145 και miR-221 συσχετίστηκαν με την λιπογένεση και τον ηπατικό μεταβολισμό, ενώ τα miR-146a, miR-223 και miR-486 συνδέθηκαν με δείκτες συστηματικής φλεγμονής. Επιγενετικές αλλαγές, όπως τροποποιήσεις στη μεθυλίωση περιοχών που …
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Su uždegimu susijusių cirkuliuojančių miRNR tyrimai periimplanto ligų diagnostikai ir prognozei /
… methods may be aided by the development of miRNAs, that regulate gene expression at the post-transcriptional level. As miRNAs have been found to be altered in expression in a number of diseases, including PI, these molecules, which are easily detectable in body fluids, have great potential …
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Characterization of the endothelial cells response to trophoblast debris
… trophoblast debris containing excessive miR-145. This engineered debris was able to partially mimic the effect of preeclamptic trophoblast debris on endothelial cell gene expression. Finally, transcriptomic analysis of endothelial cells after exposure to preeclamptic trophoblast debris …
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Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… newly identified class of small RNAs, microRNAs (miRNAs), which translationally repress the production of proteins by binding to target sites on messenger RNA (mRNA). MiRNAs provide a sophisticated way to adjust protein levels in a spatiotemporal manner. One miRNA may control several mRNAs, …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… by hydroxyurea treatment, particularly, miRNA expression. SCD patients were recruited from Yaounde Central Hospital and Laquintinie Hospital in Douala (Wonkam et al., 2018, Mnika et al., 2019 (b)), and recent migrants SCD patients from the DRC, recruited at the Haematology Clinic, Groote …