Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"miR-143"”.
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The development and characterisation of MicroRNA and gemcitabine nanotherapies for the treatment of pancreatic cancer
… expression of targeted genes. The utilization of miRNAs as therapeutic agents has showed promising rapid progress in the last 10 years but are limited because of the lack of appropriate delivery systems that will ensure reach of the pharmacological targets. On the other hand, the bottleneck with …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
… staging. • Analysis of the expression levels of miR-143, miR-200c, miR-101, miR-34b and miR-375 microRNAs of all CRC patients compared to healthy colon tissue and correlation to RAS mutational status and according to patient staging. • Correlation between SIRT6, FOXO4, HIF3A genes and miR-143, …
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Characterization of Inducible SMC-specific Drosha Knockout Mice
… cells. Recent studies have shown that microRNAs (miRNAs), a new class of small RNAs that function as guide molecules in RNA silencing, regulate and maintain the differentiation state of SMCs. A transgenic animal model to study SMC-specific knockout of Dicer, one of two RNase III proteins in miRNA …
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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… of the microRNA transcriptome showed that miR-143 is significantly under-expressed in CSX patients. This could allow phenotype switching in vascular smooth muscle cells with the resultant vascular remodelling causing reduced vessel responsiveness to local rheological stimuli and reduced …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… and/or aberrantly expressed microRNAs (miRNAs).</p> <p><strong>Material and methods: </strong>In 42 PDAC tumors, the <em>SEL1L</em> coding region was amplified using reverse transcription polymerase chain reaction (RT-PCR), and analyzed by agarose gel electrophoresis and sequenced to …
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Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… newly identified class of small RNAs, microRNAs (miRNAs), which translationally repress the production of proteins by binding to target sites on messenger RNA (mRNA). MiRNAs provide a sophisticated way to adjust protein levels in a spatiotemporal manner. One miRNA may control several mRNAs, …
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Profili di espressione dei miRNA nelle patologie vitreoretiniche.
I microRNA (miRNA) sono piccoli RNA non codificanti, in grado di regolare l'espressione genica a livello post-trascrizione e traslazionale. Diversi studi hanno dimostrato che i miRNA regolano vari processi cellulari, tra cui la differenziazione, lo sviluppo, l’invecchiamento, l’apoptosi, …
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Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… mainly focusing in non-coding microRNAs (miRNA) epigenetics control. Results showed that proadipogenic miRNAs were controlling metabolism of LM of NW-MPN steers between 78 and 187 days of age through activation of: a) miR-103 that inhibits CAV1 that destabilizes INSR increasing insulin …