Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"miR-133a"”.
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… of endothelialleukocyte interactions, with miR-133a emerging as a potential modulator of this inflammatory response. This thesis explores the role of miR-133a in endothelial activation and leukocyte adhesion, aiming to uncover new therapeutic strategies to target these pathways in …
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Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by altering the expression of key angiogenic genes
… or insufficient angiogenesis. MicroRNA (miRNA) are small non-coding RNA molecules, which inhibit gene expression by inducing mRNA degradation or suppressing protein translation. Emerging evidence highlights a novel role for miRNAs as regulators of angiogenesis. In endothelial cells …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… Studies suggest that statins affect hundreds of miRNAs, as one miRNA has the potential of binding to hundreds of mRNAs, the consequences may be enormous. However, whether these epigenetic changes lead to statin related adverse effects in South African statin users is still unknown. The aim of …
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Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
… Additionally, we demonstrated the use of joint miR-133a and miR-696 inhibition for acceleration of muscle differentiation, elevation of active contractile force amplitudes, and increasing Type II myofiber formation in vitro. </p><p>The global hypothesis that motivated this research was that …
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The Role of microRNAs in Bladder Urothelium Development and Tumorigenesis
… and progress to muscle invasion). MicroRNAs (miRNAs) are single-stranded non-coding RNA molecules, approximately 21-23 nucleotides in length, that regulate gene expression. Since their discovery in 1993, they have emerged as major mediators of cellular functions and tissue homeostasis. …