Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"miR-128"”.
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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
… neuronal intrinsic excitability by the microRNA miR-128. I show using genetic models that endogenous miR-128 plays a powerful role in dampening the excitability of pyramidal projection neurons in the adult forebrain and demonstrate that the loss of this microRNA alone results in severe motor …
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MiR-128 controls the activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its loss in gliomagenesis.
… and radio-resistance. Here we show that miR-128 directly targets the mRNA of BMI1 and SUZ12, key components of PRC1 and PRC2, respectively. This blocks the partially redundant functions of PRC1/PRC2, thereby significantly reducing PRC activity and its associated histone modifications. …