Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"miR-126"”.
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
… an unbiased screen examining expression of miRNAs, and found that miR-126 and miR-126*, whose expression are regulated by methylation of the promoter of their host gene Egfl7 inside tumour cells, were significantly negatively correlated with metastatic potential. Using both mouse xenograft …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… breast cancer metastasis to lung and bone – miR-126, miR-206 and miR-335. While miR-335 suppressed metastasis through inhibition of cell-autonomous metastatic phenotypes of cell migration and invasion, the role of miR-126 in metastasis remained unknown. Here, endogenous miR-126 is shown to …
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Biomarkers for Personalised Treatment Approach in Patients with Multiple Myeloma // Биомаркери за персонализиран подход при подбора на лечение при пациенти с миеломна болест
… to evaluate the role of circulating microRNAs (miRs) as diagnostic and prognostic biomarkers in multiple myeloma (MM). The cohort includes 56 untreated MM patients and 12 healthy controls, with a focus on the quantitative determination of expression levels of five selected miRs: miR-199a-5p, …
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Engineering Small Extracellular Vesicle-Derived Vehicles Carrying Optimized microRNA for Cardiac Repair after Myocardial Infarction
… an sEV-like vehicle (ELV) with select microRNA (miR) cargo for cardiac repair and (2) to understand the role of the sEV membrane on vesicle uptake and ELV functionality. We hypothesized that ELVs comprised of an sEV membrane and loaded with miR cargo will improve cardiac tissue repair after MI …
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MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Approaches For Better Diagnosis And Therapy
… enough for asymptomatic patients. MicroRNAs (miRs/miRNAs) are small non-encoding RNA molecules, which have been related with PDAC progression and metastasis. In particular, miR-21, miR-221, miR-155 and miR-126 have to date been shown to be highly dysregulated in human malignancies including …
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The Role of microRNAs in Bladder Urothelium Development and Tumorigenesis
… and progress to muscle invasion). MicroRNAs (miRNAs) are single-stranded non-coding RNA molecules, approximately 21-23 nucleotides in length, that regulate gene expression. Since their discovery in 1993, they have emerged as major mediators of cellular functions and tissue homeostasis. …
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Determining the role of differential expression of candidate icroRNAs in cardiometabolic diseases among South African adults living with HIV
Background: MicroRNAs (miRNAs) are potential prognostic/diagnostic markers that have been investigated for screening of cardiometabolic disease (CMD) risk in general populations. However, little is known about their value in people living with human immunodeficiency virus (PLWH), who have an …
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Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis
… as putative targets of the metastasis suppressor miRNAs, miR-126 and miR- 335. We identify PITPNC1 as amplified in nearly half human breast cancers, and overexpressed in metastatic melanoma, breast, and colon cancer. Biochemical and cellbiological experiments reveal that PITPNC1 binds to …
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ALTERAZIONE DEL miRNoma INTRACELLULARE ED EXTRACELLULARE ED ANALISI BIOINFORMATICA IN MODELLI IN VITRO DI NAFLD E DI NASH
… validato la deregolazione dei seguenti microRNA: miR-126, miR-150, miR-223, miR-483-3p, miR-1226*, miR-1290. Utilizzando un nuovo approccio computazionale per l'analisi della perturbazione delle pathway, abbiamo riscontrato che i target dei microRNA intracellulari ed extracellulari erano coinvolti …
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Developmental Deregulation and Tumorigenesis Inhibition In 14-3-3Zeta Knockout Mouse
… expressed in the 14-3-3z knockout tumors. MiR-126 was an important microRNA mediating both the lethality and tumorigenesis inhibition phenotype.</p> <p>In addition, 14-3-3z knockout mice are smaller than their litter mates. This growth retardation was accompanied with reduced growth hormone …
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miRNA expressione profiles in retinal neurodegenerative diseases
I micro RNA (miRNAs) sono piccole molecole di RNA non codificative che regolano l'espressione genica a livello post-trascrizionale e post-trasduzionale. Diversi studi dimostrano che i microRNA regolano diversi processi cellulari tra cui differenziazione, crescita, invecchiamento, apoptosi, …
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To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… biomarkers of asbestos-related LC and MPM. miRNAs regulate post-transcriptional gene expression in lung tumorigenesis and serve as promising therapeutic targets and non-invasive biomarkers due to their stability in biological fluids. Changes in miRNAs expression have been associated with …