Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"miR-122"”.
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MIR-122 and DDX6 facilitate hepatitis C virus replication via independent mechanisms
… host factors involved in HCV replication such as miR-122 and DEAD-box RNA helicase, DDX6 may facilitate development of novel therapies. miR-122 is a liver-specific microRNA that is required for efficient replication of HCV in hepatocytes. Mutational analyses of the genotype 1a/2a chimeric HCV …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… studies have suggested that the expression of miR-122 and miR-191 is decreased and increased, respectively, in hepatocellular carcinoma. However, other evidence suggests miR-122 may be preserved in HCV-associated hepatocellular carcinoma (HCC). The goal of this thesis is to assess miR-122 and …
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A Genomic Portrait of Hepatitis C Virus and MicroRNA-122
… uniquely requires the liver specific microRNA-122 (miR-122) for replication, yet global effects on endogenous microRNA (miRNA) targets during infection are unexplored. In this body of work, we employed highthroughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of …
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MicroRNA-122 and Poly(C)-Binding Protein 2 Bind to the Hepatitis C Virus Genome, Regulating Viral Replication and Genome Structure
… been suggested that the host factors, microRNA-122 (miR-122) and poly-(C) binding protein 2 (PCBP2), may regulate these two processes. These host factors promote HCV replication and compete for overlapping binding sites on the 5’ untranslated region (UTR) of the HCV genome. This work …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… aim of these studies was to identify circulating miRNAs that can be used as biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
… currently used in AT-DILI diagnosis. MicroRNA-122 (miR-122) is a sensitive biomarker for liver injury due to paracetamol, but data on utility as a biomarker for ATDILI are limited. Methods: We conducted a randomized double-blind placebo-controlled trial of intravenous NAC in adult hospitalized …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… has been previously described. Serum microRNA-122 (miR-122) has shown liver specificity and higher sensitivity than alanine aminotransferase (ALT) and High mobility group box 1 (HMGB1) is an informative and early serum indicator of cell death and inflammatory processes in Paracetamol …
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Use of Molecular Methods to Authenticate Animal Species and Tissue in Bovine Liver Dietary Supplements
… and real-time PCR testing for microRNA-122 (miR-122), which is highly expressed in liver tissue. Multiplex real-time PCR targeting domestic cattle (<em>Bos taurus</em>), horse (<em>Equus caballus</em>), sheep (<em>Ovis aries</em>), and pork (<em>Sus scrofa</em>) was used to verify …
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Ο ρόλος της Γενετικής και Επιγενετικής ρύθμισης με microRNA στην παιδική παχυσαρκία
… σε παιδιά με παχυσαρκία. MicroRNA όπως τα miR-26b, miR-122, miR-145 και miR-221 συσχετίστηκαν με την λιπογένεση και τον ηπατικό μεταβολισμό, ενώ τα miR-146a, miR-223 και miR-486 συνδέθηκαν με δείκτες συστηματικής φλεγμονής. Επιγενετικές αλλαγές, όπως τροποποιήσεις στη μεθυλίωση περιοχών που …