Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"miR-10a-5p"”.
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Downregulation of miR-10a-5p as a Potential Therapeutic Target to Improve the Detrimental Effects of Post-stroke Social Isolation
… that SI leads to dysregulation of microRNA (miRNA) networks in the brain. miRNAs affect gene regulation posttranscriptionally by binding to target mRNAs thus repressing protein production of the target mRNAs. Using an aged mouse stroke model, we found the top dysregulated miRNA in aged male …
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Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat
… expression profiles of EtOH-sensitive microRNAs (miR-10a-5p, miR-26a, miR-32, miR-103 and miR-495), E<sub>2</sub>-responsive microRNAs (miR-7a, miR-9, miR-125a and miR-181a), BDNF, SIRT1, Drosha and Dicer are differentially dependent on sex and age throughout pubertal development. This research …
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Micrornas As A Therapeutic Target to Regulate Microglial Activation In Post Stroke Isolation In Aged Male Mice
… amyotrophic lateral sclerosis (ALS). MicroRNAs (miRNAs), a class of 18-25 nucleotide non-coding RNAs, have been shown to regulate the activation of microglia from a resting state to “disease-associated microglia (DAM)”. Preliminary work in the laboratory has shown post-stroke SI significantly …