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Showing 1 to 7 of 7 for “"mexab"”.
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Regulation of the MexAB-OprM Multidrug Efflux System of Pseudomonas aeruginosa: Involvement of Pentachlorophenol and Plant Chemicals
… mediated by multidrug efflux systems. The MexAB-OprM efflux system is constitutively expressed in wildtype strains and contributes to innate antimicrobial resistance, while hyperexpression of the system results in acquired high levels of resistance. MexAB-OprM is hyperexpressed in nalC …
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Computational Study on MFP MexA in MexAB-OprM and RND transporter AcrB in AcrAB-TolC Efflux Pumps
… in P.aeruginosa and E.coli / Salmonella, MexAB-OprM and AcrAB-TolC respectively. In particular, we studied the possible multimerization of the MFP component MexA and the effects of mutations in the AcrB distal binding pocket. The starting point for the first part of our study was the …
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The Role of Multidrug Efflux Pumps in the Stress Response of Pseudomonas aeruginosa to Organic Contamination
… nodulation-cell division (RND) efflux pump, MexAB-OprM, in particular is responsible for the PCP-induced increase in antibiotic resistance. Both whole cell physiological indicators and whole genome analysis were used to examine the stress response of <i>P. aeruginosa</i> to PCP. Cells were …
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Structural characterization of superbug proteins involved in regulating beta-lactam resistance
… that overexpress multidrug efflux pumps such as MexAB-OprM. Production of MexAB-OprM is controlled by the MarR family repressor, MexR, and several hyper-resistant strains of P. aeruginosa appear to involve mutations in either MexR or additional regulatory factors upstream of MexR. The allosteric …
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Characterization of the MexT Regulator of the mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa
… MexT also negatively regulates the expression of mexAB-oprM through direct binding to its promoter region and the oprD gene, encoding an outer membrane porin that provides a portal of entry for basic amino acids and carbapenem, whose expression was reduced only by GSNO.
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… four of the well characterized efflux pumps, mexAB-oprM, mexCD-opri, mexEF-oprN, and mexXY, were shown to be expressed in a wild-type susceptible strain of P. aeruginosa. The effect of growth-phase on expression of these pumps had varying results depending upon which RNA isolation method and …
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Regulation of Outer Membrane Porins in P. aeruginosa Strains Collected from Patients with Cystic Fibrosis
… along with an increased expression of the mexAB-oprM efflux pump with a concomitant down-regulation or loss of the OprD porin. 2) Carbapenem exposure can select mutants that exhibit increased susceptibility to multiple antibiotics, which is not associated with modifications in the …