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Showing 1 to 20 of 37 for “"mevalonate pathway"”.
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Variations in Mevalonate Pathway Flux in Human Cells with Familial Hypercholesterolemia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
… Radiolabeling experiments with acetate and mevalonate strongly implicate the mevalonate pathway in providing the isoprenoids for archaeal lipid biosynthesis. However, the enzymes responsible for mevalonate metabolism in archaea have remained either cryptic or poorly characterized. To …
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Inhibition of enzymes from the non-mevalonate pathway using fragment-based approaches
… against two essential target proteins in the non-mevalonate pathway (MEP), 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from *D.radiodurans* and 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) from *E.coli*. There have been only a handful of reports of small molecules developed to target …
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The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
… in the expression of genes related to the mevalonate pathway. We also found that simvastatin, an inhibitor of the mevalonate pathway, induced GBM stem cells death.</p> <p>This study showed mitochondria metabolic reprograming of GBM stem cells during differentiation. It also showed the …
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Association between Genetic Polymorphisms of Enzymes Involving Mevalonate Pathway(GGPS1 and FDPS) and Bone Mineral Density Response to Bisphosphonate Treatment
Geranylgeranyl diphosphate synthase1(GGPS1)과 farnesyl diphosphate synthase(FDPS)는 골다공증 치료제인 질소 함유 비스포스포네이트가 억제하는 표적효소로, 환자마다 비스포스포네이트에 대한 반응이 달리 나타나는 이유는 이 표적효소들의 유전자 다형성에서 기인하는 부분이 있을 것으로 생각된다. 본 연구의 목적은 GGPS1, FDPS 유전자에서 한국인 고유의 유전자 다형성을 찾고, 이에 따라 비스포스포네이트 투여에 대한 반응에 차이가 있는지를 평가하는 것이다. 골다공증 외에 …
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Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
… HMG-CoA Reductase, downstream enzymes in the mevalonate pathway, and G-protein Ggamma 1, which is geranylgeranylated, thus representing an endpoint of isoprenoid biosynthesis. These findings reveal a cardial cell-autonomous requirement of Ggamma 1 geranylgeranylation for heart formation and …
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On connections between metazoan cellular metabolism and cell size
… biosynthesis and especially with inhibitions of mevalonate pathway. Systematic dissection of the mevalonate pathway revealed that protein geranylgeranylation is required for maintaining normal cell size and proliferation ratio. Geranylgeranylation of the recycling endosome regulating protein …
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The cloning and molecular regulation of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase
… reductase the key regulatory enzyme in the mevalonate pathway. The amino acid sequence of rat HMG-CoA reductase is highly homologous to hamster and human reductases. Noncoding regions of the reductase mRNAs are also highly conserved. Rat HMG-CoA reductase mRNA is initiated at a single …
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Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer
… Modulation of critical oncogenic signaling pathways has been shown to phenotypically revert breast cancer cells to a more acinar-like morphology. We examined the role of mutant p53 in this context by generating stable, regulatable p53 shRNA derivatives of mammary carcinoma cell lines to …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… ability to inhibit more than one enzyme in the mevalonate pathway.
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Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation
… on de novo cholesterol synthesis through the mevalonate pathway to meet the tissue's requirement for this essential lipid. A small amount of brain cholesterol is turned over daily in select neurons by cholesterol 24-hydroxylase, which catalyzes the production of the membrane-permeable …
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Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
… to the type of p53 mutation. Upregulation of mevalonate pathway expression was observed only in R270H lung tumours and consequently R172H and R270H lung tumours displayed distinct sensitivities to simvastatin, a mevalonate pathway inhibitor widely used in the clinic. Furthermore, the …
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Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity
… which catalyzes the reduction of HMG-CoA to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis constituting one of the obligate routes to producing the …
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Wpływ bisfosfonianów stosowanych w terapii osteoporozy na metabolizm tlenowy komórek śródbłonka
… farnesylpyrophosphate synthase (FPPS) in the mevalonate pathway. The mevalonate pathway plays an important role in many cellular processes such as protein prenylation and post-translational modifications as well as the synthesis of molecules containing isoprenoid units, including a-hemes …
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and inhibition of isoprenoid synthases in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, and …
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… interfering with the rate-limiting step of the mevalonate pathway. Geranylgeranylpyrophosphate and farnesylpyrophosphate induce post-translational modifications in RAS that anchor the protein to the cell membrane so that it acts as a signal transducer to the nucleus, promoting cell proliferation.
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The design and synthesis of novel potential antimalarial compounds
… Each section covers a different biological pathway, its current importance as a potential drug target, and the syntheses towards a selection of natural products and analogues relevant to the pathway. In Section A, the novel approach towards a new class of n-formyl amides is described. …
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… reductase, a rate limiting enzyme in the human mevalonate pathway of which cholesterol in the biosynthetic end product. The mevalonate pathway is an important cellular metabolic pathway present in many bacteria. Hence, the aim of this study was to assess the in vitro efficacy of statins against …
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The Effects of Aqueous Atorvastatin on Steroidogenesis of <i>Xenopus laevis</i> at Environmentally Relevant Concentrations
… inhibiting production of mevalonic acid in the mevalonate pathway. Atorvastatin (Lipitor) is one of the most widely prescribed statin drugs and contamination of wastewater effluent is a growing environmental concern because of the potential to interfere with steroidogenesis in wildlife. …
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