Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"methylthioadenosine"”.
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Purification and Characterization of 5'-Methylthioadenosine Nucleosidase From Avocado and Tomato
Activities of MTA nucleosidase and 5-methylthioribose kinase were determined in ripening 'Rutgers' and non-ripening ' rin' and 'nor' tomatoes during fruit development. The effects of wounding on MTA content and MTA nucleosidase activity were also assessed. Results suggested that the methionine …
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
<p>Homozygous deletion of methylthioadenosine phosphorylase (<em>MTAP</em>) is a frequent genetic alteration found in approximately 15% of all human cancers, including glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder carcinoma, and lung squamous cell carcinoma. MTAP is a critical …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… identified in GBM is homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene, which occurs in 50% of all GBM cases. Despite its common occurrence, it is unclear what contribution MTAP loss makes in the pathogenesis of GBM or whether this genetic alteration can be used as a …
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Mechanistic aspects of thiamine biosynthesis in escherichia coli
… inhibition could be alleviated by addition of 5‘-methylthioadenosine / S-adenosylhomocysteine nucleosidase (MTAN), which catalysed rapid hydrolysis of DOA to adenine and 5‘-deoxyribose. The addition of MTAN increased the activity of the ThiGH complex but drastically increased the amount of …
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Methanocaldococcus jannaschii and the Recycling of S-adenosyl-L-methionine
… metabolites: S-adenosyl-L-homocysteine (SAH), methylthioadenosine (MTA), and 5'-deoxyadenosine (5'-dA). Each of these has been demonstrated to be feedback inhibitors of SAM dependent enzymes. Thus, each metabolite has a pathway to prevent inhibition through the salvage of nucleoside and ribose …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… the exogenous addition of epinephrine but not 2-methylthioadenosine diphosphate (2MeSADP), which suggests that lipid raft disruption effects P2Y12-mediated Gi activation but not Gz. Phosphorylation of Syk (Y525/526) and PLCγ2 (Y759), were not affected by raft disruption in CLEC-2 …