Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"methyllanthionine"”.
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… crosslinks dubbed lanthionine (Lan) and methyllanthionine (MeLan). The evolvability and brevity of lanthipeptide biosynthetic pathways as well as the substrate tolerance of the biosynthetic machinery facilitates the heterologous expression of lanthipeptides and renders the …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… thioether residues lanthionine (Lan) and methyllanthionine (MeLan). Installation of thioether crosslinks in lanthipeptide biosynthesis is carried out by designated synthetases and involves dehydration of Ser/Thr residues and cyclization via Michael-type addition. The remarkably broad …
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Investigations into the roles and molecular mechanisms of LanC-like proteins
… thioether crosslinks lanthionine and methyllanthionine. Among the various biological activities that lanthipeptides exhibit, the anti-microbial activities shown by many members of the family (hence named lantibiotics) have drawn the most attention and make them promising antibacterial …
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Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
… thioether-containing crosslinks lanthionine and methyllanthionine and includes many members with promising activities against clinically-relevant bacterial pathogens, including drug-resistant strains. These peptides are biosynthesized by translation of a linear precursor peptide on the ribosome, …
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Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis
… bearing characteristic lanthionine (Lan) and/or methyllanthionine (MeLan) bridges. Many of them display potent antimicrobial activities, such as the class I lanthipeptides nisin and microbisporicin. However, the mechanism of one key step in their biosynthesis – dehydration – was still mysterious, …
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Biomedical applications for bacteriocins in infection and oncology
… (Dha), dehydrobutyrine (Dhb) and lanthionine/ methyllanthionine. Interest in using bacteriocins as alternative therapeutics in multiple settings has grown in recent years. Nisin in particular has been the subject of many studies due to it being well characterised, approved by the FDA, widely …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
… contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) structures that contribute to their diverse biological activities. ProcM is a promiscuous bifunctional synthetase that catalyzes both dehydration and cyclization of the lanthipeptides. Its 30 substrate peptides (ProcAs) …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
Ribosomally synthesized and post-translationally modified peptides are a family of natural products with diverse activities, with lanthipeptides as one of the most prominent classes. The diverse ring topology of lanthipeptides is formed by four classes of enzymes with substrate tolerance that holds …