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Showing 1 to 12 of 12 for “"methylenetetrahydrofolate"”.
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The Impact of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in a Paraquat Mouse Model of Parkinson’s Disease
… play a role. A common polymorphism (677C>T) in methylenetetrahydrofolate reductase (MTHFR), a folic acid metabolism enzyme, is associated with increased PD incidence. Using a mouse model that mimics this polymorphism, this study aimed to determine whether MTHFR deficiency leads to enhanced …
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Regulation of the GCV3 gene in Saccharomyces cerevisiae
… 3 . Concomitantly it generates the C1-donor 5,10-methylenetetrahydrofolate and the electron donor NADH. NH 3 is an important precursor for cellular nitrogen metabolism. The C1-donor 5,10-methylenetetrahydrofolate is a precursor for the biosynthesis of C1-end products such as adenine, thymidylate, …
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A MOLECULAR ORBITAL STUDY OF 5-FLUOROURACIL AND RELATED COMPOUNDS
… synthetase, and the co-factor, N('5), N('10)-methylenetetrahydrofolate. The effect of replacing the hydrogen bonded to the 5-position of the pyrimidine ring by a fluorine atom is also mechanistically described. A molecular orbital study employing the CNDO/2 approximation was performed on …
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Methotrexat-induzierte Leukenzephalopathie bei Patienten mit akuter lymphatischer Leukämie oder lymphoblastischem Non-Hodgkin-Lymphom in Abhängigkeit vom MTHFR-C677T-Status
… of pediatric Acute Lymphatic Leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate metabolism, so that combination of MTX-therapy and mutation of the MTHFR gene (MTHFR C677T) might result in altered toxicity. We examined 31 children with ALL or NHL, that …
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THE ROLE OF MTHFR GENE MUTATION IN NEURODEVELOPMENTAL DISORDERS: EXPLORING POTENTIAL CORRELATIONS WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ANXIETY
… of ADHD is agreed to be a prevalent problem. The methylenetetrahydrofolate reductase (MTHFR) gene has been identified as a possible contributor to ADHD. The goal of this research is to decrease the frequency at which ADHD is misdiagnosed by investigating the correlation between the MTHFR gene at …
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Genetic Association Study of Osteoporotic Vertebral Compression Fractures in Postmenopausal Women
… low body mineral density, and fracture. 5, 10-Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are involved in homocysteine metabolism. Thus, we determined whether or not VEGF, MTHFR, and TS polymorphisms are associated with osteoporotic vertebral compression fractures …
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Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status.
… variation of the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) or estrogen receptor α and β expression of tumors. Food habit information and blood samples were collected 1991-96 from 17 035 women between 45 and 73 years in the MDC study. Until end of 2004, 544 cases …
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Excited state charge redistribution and dynamics of flavins, flavorproteins, and their cofactors
… and its photodecomposition product, 5,10-methylenetetrahydrofolate. The difference dipole moments for the lowest energy transitions of both of these chromophores were found to be quite large, ranging from 9-12 D fc and lying primarily along the transition dipole moment. Additionally, the …
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The Mechanism of N10-Formyltetrahydrofolate Synthetase. Use of Human Thymidylate Synthase Variants to Characterize Asymmetric Ligand Binding and to Identify Novel Allosteric Inhibitors.
… It catalyzes the transfer of a methyl group from methylenetetrahydrofolate (mTHF) to deoxyuridine monophosphate (dUMP) to form deoxythymidine monophosphate (dTMP). This enzyme has two conformations of catalytic loop 181-197, which is unique among TS enzymes. One of the conformations places crucial …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… the enzymes dihydrofolate reductase (DHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) or serine hydroxymethyltransferase (SHMT) which are required to regenerate 5, 10-methylenetetrahydrofolate. MTHFD1 is the primary source of 5,10-methylenetetrhydrofolate generation, and therefore …
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Which Gene is a Dominant Predictor of Response during FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, MTHFR or XRCC1 Gene?
"국문요약 ------------------------------------------- i 차례 ----------------------------------------------- iv 그림 차례 ------------------------------------------- v 표 차례---------------------------------------------- vi I. 서론 ------------------------------------------ 1 II. 연구대상 및 …
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Trombose da veia porta em crianças e adolescentes : deficiência das proteínas C, S e antitrombina e pesquisa das mutações fator V Leiden, G20210A da protrombina e C677T da metileno-tetraidrofolato redutase
Objetivo: A trombose da veia porta é uma causa importante de hiper-tensão porta em crianças e adolescentes, porém, em uma proporção importante dos casos, não apresenta fator etiológico definido. O objetivo desse estudo é determinar a freqüência de deficiência das proteínas inibidoras da coagulação …