Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"methylation profiling"”.
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DNA methylation detection using an engineered methyl-CpG-binding protein
DNA methylation, specifically the methylation of cytosine bases, is an important biomarker, as abnormal DNA methylation patterns are found in many different types of cancer. Currently, a small number of cancer hospitals evaluate the methylation status of the MGMT gene promoter to determine the best …
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
… study aimed to develop a gene-specific DNA methylation tool for non-invasive and early kidney cancer diagnosis and follow-up. Genome-wide DNA methylation profiling utilizing microarrays allowed the identification of a set of novel presumable ccRCC-specific DNA methylation biomarkers, having …
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Deciphering the genetic and epigenetic basis of human imprinting and chromatin disorders
Aberrant DNA methylation patterns, including disturbances in genomic imprinting, have been linked to congenital imprinting disorders as well as various disease conditions, including cancer, chromatin disorders, and neurodevelopmental disorders. Some imprinting disorders, however, result in …
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
… therapies. By combining histological review, methylation profiling, whole-genome and whole-exome sequencing, gene expression profiling, and copy number analysis of a large cohort of DIPG, we describe differences to adult disease, uncover mutations in novel cancer drivers, histone H3 mutation …
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The DNA methylation landscape of metastatic prostate cancer: from characterization to liquid biopsy applications
… in tumorigenesis and evolution. The role of DNA methylation has been particularly elusive in this context. While this epigenetic mark has been extensively profiled in healthy and cancerous samples, our ability to understand its relationship with underlying biological processes is still limited. …
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Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… depends upon correct patterning of DNA methylation over imprinted domains during oogenesis. It was previously shown that oocytes deficient in the human SCMC gene *KHDC3L* had globally impaired methylation, thus suggesting a role for the SCMC in the establishment or maintenance of DNA …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… (PRC2) components. This complex catalyzes the trimethylation of Lysine 27 on histone 3 (H3K27me3), thereby repressing transcription during embryonic development. However, our understanding of how PRC2 dysfunction affects cortical development, and how WVS heterozygous mutations impact H3K27 …
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Molecular characterization of methylated circulating tumour DNA biomarkers and their detection with low-cost biosensor
… The challenge in prostate cancers is that the methylation levels are notoriously heterogeneous, which may lead to misclassification in a subset of patients. In this thesis, machine learning was coupled with a similar target-enrichment method, cell-free Methylation Binding Domain 2-sequencing …
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Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… with age (r=-0.15, p</p> <p><strong>II. METHYLATION IN SERUM CELL-FREE DNA AND CPG-SNP WITH BLADDER CANCER RISK</strong></p> <p>Epigenetic alterations are early events of cancers, including bladder cancer. In the present study, we aimed to examine methylation profiles of circulating DNA …
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The Placenta Methylome: Novel Insights into DNA Modifications in the Human Placenta
The DNA methylation profile of the placenta is unique as compared to other somatic tissues and is marked by global hypomethylation. The placental methylome has been shown to modulate developmental processes, intrauterine exposures, and placental function. However, the precise mechanisms underlying …
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The Epigenetics of Small Cell Prostate Cancer
… we observed a low frequency of AR promoter methylation found in samples that lacked AR expression despite previous publications, which led to further analysis of possible silencing mechanisms. Using ChIP-qPCR, we found that the AR promoter is enriched in silencing histone modifications …
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Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
… structural abnormality – dup(1q)? Are aberrant methylation patterns involved in leukemogenesis? How do diagnostic and relapse samples relate to each other genetically? In article I we found that the proximal breakpoints of dup(1q)-positive Burkitt lymphomas (BL) and pediatric HeH ALLs cluster …