Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"methyl methanesulfonate"”.
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The effects of actinomycin on deoxyribonucleic acid treated with methyl methanesulfonate
Call number: LD2668 .T4 1968 M3244
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The effects of actinomycin on deoxyribonucleic acid treated with methyl methanesulfonate
Call number: LD2668 .T4 1968 M3244
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High-throughput genomic phenotyping
… manner and in response to the alkylating agent methyl methanesulfonate (MMS). The first method makes use of a new technology called the Living ChipTM, which can hold libraries of compounds or cell cultures in an array of 50-nl channels and which could ideally accommodate all deletion strains on …
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Exploring the biological functions of AlkB proteins and how they relate to AAG
… (ABH2 and ABH3), and how they relate to the 3methyladenine DNA glycosylase (AAG). AAG is a base excision repair (BER) protein that has been well-studied and is known to be involved in the repair of a wide variety of substrates. On the other hand, the direct reversal protein AlkB, and its human …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… distinct toxicants: hydrogen peroxide, methyl methanesulfonate, arsenite, and hypochlorite. Multivariate statistical analysis revealed both dose- and agent-specific signatures in the relative quantities of tRNA modifications. Further, modifications that change significantly after …
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The mechanism of cyanamide/MMS-induced DDI2/3 expression in Saccharomyces cerevisiae
… can be highly induced by DNA-damaging agent methyl methanesulfonate (MMS). They share identical coding sequence and their promoter sequences are also highly conserved, which are referred as DDI2/3 in this dissertation. Subsequent studies revealed that DDI2/3 encode a cyanamide (CY) hydratases …
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Genetic and Cytological Analysis of the Spindle Assembly Checkpoint Component BUB-3 in DNA Damage Response
… drug cisplatin but not to UV light or methyl methanesulfonate. This is consistent with a role in dealing with DNA double-strand breaks and not with base damage. bub-3 and san-1 mutants did not exhibit a mutator phenotype, which suggests that these genes are not required to preserve …
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Studies of tumor promoters and drug-metabolic enzymes in hamster buccal pouch mucosa
… skin tumor promoters, okadaic acid (OA) and methyl methanesulfonate (MMS), on HBPM. Short term effects of OA were studied. A single application of10 1.1.g of OA in 0.1 ml of acetone produced marked inflammation as well as an increased mitotic rate (p<0.01) as compared to that of the control. …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
Methylating agents are ubiquitous in our internal and external environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused …
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Synthetic approaches to the understanding of DNA nucleobase methylation
DNA methylation is a major source of genetic variation and cancer. Methylation occurs when nucleophilic DNA bases react with methylating agent methyl methanesulfonate (MMS), dimethyl sulfate (DMS), N-methyl-N-nitrosourea (MNU), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), etc. …
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Determination of genotoxic stress in feral populations of bullheads and carp using the alkaline single cell gel assay.
… of two direct acting mutagenic agents (methyl methanesulfonate (MMS) and N-methyl-N-nitrosourea (NMU)), two indirect acting mutagens (benzo(a)pyrene (B(a)P)) and 7,12-dimethylbenz(a)anthracene (DMBA) and two cell cycle specific agents (methotrexate (MTX) and colchicine) over a range of …